Can Martial Arts Training Make a Difference to Mental Health?

Matching Movement to the Individual Through Regulation, Agency and Meaning

Chris People and Daniel Mirea (23 October 2026)
| The NeuroAffective-CBTยฎ Journal |

Introduction

Combat training and mental health hardly seem to belong in the same sentence. The connection is counterintuitive. Combat suggests aggression, confrontation and the possibility of harm. Concerns about injury, including brain injury in activities involving head contact, are real and deserve attention (Neidecker et al., 2019). Why, then, consider martial arts within a discussion of psychological wellbeing?

To a keen observer, the answer may emerge through the training itself. What becomes apparent is how much attention is given to the art: learning movement, judging distance, coordinating effort, responding to another person and exercising control. In a supportive training environment, these abilities develop gradually, with the intensity and physical demands adjusted as the participant gains familiarity and skill.

Martial arts also have a substantial interpersonal dimension. Individual practice is important, but partner exercises introduce something different: another person whose movement, timing and response cannot always be fully predicted. The participant must attend, interpret and act while remaining aware of their own reactions. They may need to communicate a limit, request a slower pace, accept correction or manage the frustration of getting something wrong.

Breathing is often part of this learning. In some traditions, explicit instruction in breathing accompanies the development of posture, movement and control from an early stage. Japanese martial traditions may direct focused attention towards the hara, while Chinese practices such as Tai Chi emphasise the lower dantian, traditionally understood as a centre of vital energy (Mai, 2015; National Qigong Association, 2025). These concepts provide ways of organising attention around the abdomen, breathing and coordinated movement. Breathing becomes something to notice and coordinate with action, particularly as effort and intensity change.

Figure 1: Karate meditation (mokusล): bringing attention to the hara (the lower abdomen) through an upright, relaxed posture and gentle abdominal breathing.

Attention, bodily awareness, breathing, gradual engagement with discomfort and responsiveness to others are also familiar concerns within mindfulness and emotional regulation approaches. Their presence in martial arts makes the clinical connection worth exploring. What might a participant be learning psychologically while practising physically? Could these experiences be connected more deliberately with therapeutic goals?

Our observations and individual experiences suggest that participants can learn more than the execution of a technique. Someone who initially responds with excessive tension, hurried movement or withdrawal may gradually become more able to pause, direct attention, adjust effort and choose what to do next. Another may discover that asking for help or expressing a boundary allows participation to continue. These experiences may acquire psychological significance even when neither instructor nor participant describes them in therapeutic language.

From a NeuroAffective-CBT perspective, lifestyle interventions are an essential part of promoting health and resilience. We propose that appropriately selected martial arts training may provide a practical setting for rehearsing regulation and agency. The relevant learning will differ between individuals. It may involve remaining engaged while uncomfortable, responding less harshly to mistakes, exercising restraint or recognising when to stop. These possibilities depend on the training environment, the quality of instruction and the meaning the person gives to participation.

Matching movement to the individual is therefore central. Preferences, physical capacity, cultural meaning, access and recovery all influence whether an activity is suitable and sustainable. The same exercise may offer one person an experience of capability while becoming another demand through which someone else judges or punishes themselves. Understanding that difference belongs within therapeutic formulation.

This selective narrative review brings together exercise and martial arts research with clinical reasoning and observations from training. Drawing on NeuroAffective-CBT alongside established cognitive behavioural approaches, we examine how chosen and adapted participation might support attention, coping self-instruction, assertiveness, mastery and belonging. A hypothetical clinical illustration shows how physical practice can be connected with a specific prediction, collaborative review and an experiment outside training.

The wider exercise literature supports therapeutic relevance, while evidence specific to martial arts remains heterogeneous. Our observations inform the proposed applications rather than establish their effectiveness. The question is how particular forms of training, matched to the individual and delivered within suitable conditions, might support mental health and whether what is learned during practice becomes available in everyday life.

Keywords: martial arts; combat sports; lifestyle interventions; cognitive behavioural therapy; NeuroAffective-CBT; emotional regulation; agency; psychological flexibility; therapeutic learning.

Martial Arts and the Cultivation of Mind and Body

Organised combat practices have a documented history extending across millennia and cultures. Wrestling entered the ancient Olympic programme in 708 BCE, boxing in 688 BCE and pankration, which combined striking and wrestling, in 648 BCE. These dates concern their inclusion in the Games rather than the origins of combat practice, but they demonstrate the longstanding place of fighting skills within organised physical culture (Foundation of the Hellenic World, n.d.).

The history of Chinese martial arts provides a further connection between physical practice, cultural meaning and self-cultivation. Shahar (2008) documents the involvement of Shaolin monks in seventh-century military events and traces the subsequent development of their martial traditions. This history encompasses armed and unarmed practices, religious commitments and relationships with political institutions. Later developments also connected martial practice with therapeutic purposes. Shaolin represents one important tradition within a diverse history, illustrating how fighting skills could become associated with broader understandings of health, discipline and personal development.

In the twentieth century, Bruce Lee brought the relationship between martial practice and personal philosophy to a wide international audience. His reflections emphasised adaptability, self-expression and learning through experience. His water metaphor presented responsiveness as an alternative to rigidly imposing a predetermined form. These ideas offer a philosophical connection with contemporary interests in psychological flexibility and agency, although Lee was articulating a philosophy of practice rather than a clinical treatment model (Bruce Lee Enterprises, n.d.).

Accounts of Leeโ€™s recovery following a serious back injury add a personal dimension to this relationship. His family describes pain and emotional difficulty, extensive study, rest and a cautious return to movement. This account illustrates purposeful engagement with physical limitation, bringing reflection, learning and action together. It remains a biographical account rather than evidence that determination or self-instruction alone repaired the injury (Bruce Lee Enterprises, 2017).

Clinical interest in these connections also has an established history. Fuller (1988) discussed parallels between martial arts and psychotherapeutic concepts, including possible clinical applications. Twemlow and Sacco (1998) described therapeutic applications with adolescents presenting with violent behaviour. These contributions provide a foundation for asking how particular experiences within training might become relevant to an individualโ€™s psychological difficulties and treatment goals.

Beyond the instruction to exercise

Recommending exercise can leave the main therapeutic problem untouched. A person may understand that movement could help and still feel unable to enter a gym, tolerate being a beginner or return after a difficult first session. Shame, fatigue, anticipated judgement and practical barriers can make an apparently simple recommendation difficult to act upon.

Clinical work therefore needs to address how participation becomes possible and what the person learns through it. A correction might be interpreted as evidence of inadequacy or as ordinary assistance in learning. Asking for a pause might feel humiliating or become an experience of effective choice.

The same activity can serve different functions. Training may support curiosity and connection, reinforce punitive standards or provide temporary escape from distress. Its therapeutic significance depends on the personโ€™s formulation and experience. Salkovskis et al. (2023) describe therapy in terms of a shared understanding that is tested to enable more flexible responding. Applied to movement, this directs attention to the expectations being examined and the responses being practised.

Established approaches such as graded engagement, behavioural experiments and coping rehearsal provide methods for connecting physical practice with psychological learning. NeuroAffective-CBT offers one organising perspective for considering bodily regulation, protective responses and embodied rehearsal within this work.

Scope and approach

This selective narrative review is intended primarily for clinicians working with adults. Sources are brought together according to their relevance to exercise outcomes, martial arts and boxing, participation and candidate psychological processes. Systematic reviews and meta-analyses inform the evidence overview; selected trials and conceptual publications address particular clinical questions. The synthesis is purposive and does not claim exhaustive coverage or an independent formal quality appraisal.

General exercise findings are distinguished from evidence concerning particular disciplines and interventions. Outcomes are also distinguished from the mechanisms proposed to explain them. NeuroAffective-CBT publications provide conceptual and practitioner perspectives rather than independent empirical validation of the integrated approach.

The clinical proposals additionally draw on the authorsโ€™ observations and individual experiences of training. These inform hypothesis development rather than constitute systematically collected outcome data. The worked illustration is hypothetical, and no original patient data are reported.

What participants actually do

Martial arts and combat sports overlap, but neither label defines a uniform intervention. Traditional forms, non-contact boxing, recreational grappling and competitive mixed martial arts involve different movements, expectations and exposures. A practice may emphasise cultural tradition, self-defence, fitness or competition.

For clinical interpretation, important distinctions concern contact, sparring, exertion, instruction and freedom to stop. Shadowboxing and pad work can use striking movements without participants receiving blows. Grappling involves close physical contact and its own injury exposures. Recreational training and competition can differ substantially even within one club.

The learning environment matters alongside these physical ingredients. An instructor who welcomes questions and adapts tasks creates different opportunities from one who treats uncertainty or stopping as weakness. Community membership, traditional philosophy and shared rituals may matter in some settings and be absent in others.

An individualised recommendation therefore needs to specify what the person will do, with whom, under which conditions and for what purpose. The clinical applications discussed here concern mainly recreational training and adapted non-contact activities. Contact and competition remain separate choices rather than necessary stages of therapeutic progress.

What the exercise evidence supports

Physical activity has a substantial evidence base in mental health. Singh et al. (2023) brought together 97 systematic reviews covering 1,039 trials and 128,119 participants, reporting improvements in depression, anxiety and psychological distress across varied adult populations. However, 77 reviews received a critically low AMSTAR-2 methodological quality rating. These ratings concern the reviews rather than 77 individual trials.

Noetel et al. (2024) found benefits for several exercise modalities in depression, including walking or jogging, yoga and strength training, with confidence in estimates limited by study quality and other uncertainties. Gordon et al. (2018) identified an average reduction in depressive symptoms across 33 resistance-training trials involving 1,877 participants.

The evidence supports considering several forms of movement while leaving their selection and delivery open to individual planning. An advantage over inactivity or usual care may reflect structure, encouragement, expectation and social contact as well as exertion. Comparison with another credible activity asks a more specific question about relative benefit.

White et al. (2024) reviewed 247 studies examining mediators and moderators of the relationship between physical activity and mental health. Their synthesis identified support for self-esteem, self-efficacy, physical self-worth and social connection, with more qualified support for mastery and mindfulness. Most included studies were observational. These findings identify plausible processes for investigation while leaving uncertainty about causal pathways in an individual client.

Evidence specific to martial arts and boxing

Moore et al. (2020) synthesised 14 studies and reported a small pooled benefit for wellbeing and a moderate pooled effect on internalising mental health outcomes. Heterogeneity was substantial, particularly for internalising outcomes, and the pooled aggression finding was not statistically significant.

Ciaccioni et al. (2024) reviewed 72 observational adult studies, comprising 70 cross-sectional and two longitudinal studies. Findings varied across self-related, emotional and cognitive outcomes. The designs limit conclusions about whether differences resulted from training, pre-existing characteristics or continued participation by people who found the activity helpful.

Non-contact boxing is a closer comparison for interventions using pads, bags and combinations. Bozdarov et al. (2023) identified 16 studies across diverse populations and delivery formats. In 56%, boxing was supplemented by components such as mentoring, mindfulness or psychological strategies. The review maps promising applications, but the mixture of designs and combined interventions prevents a firm estimate of boxingโ€™s independent contribution.

Weiss et al. (2025) provide a recent clinical example. Their 24-person pilot examined taekwondo and mindfulness within a dialectical behaviour therapy intensive outpatient programme. Participants reported favourable acceptability and immediate affective changes. The small within-subject study, conducted during ongoing treatment, supports feasibility and further investigation.

Together, these findings support studying specified practices in defined contexts. They leave open which components contribute to change and how outcomes compare with other meaningful activities.

Lifestyle interventions within NeuroAffective-CBT

Lifestyle interventions address recurring conditions of daily life that affect wellbeing and participation. Sleep, movement, nutrition, hydration and recovery can influence one another. Fatigue may reduce the capacity to attend a class, while an excessively demanding training schedule may interfere with rest. These conditions belong within formulation when they contribute to difficulties or limit engagement with treatment.

Within NeuroAffective-CBT (NA-CBT), TED refers to Tirednessโ€“Exerciseโ€“Diet. Mireaโ€™s exercise discussion emphasises individualisation and meaningful participation (Mirea, 2025a), while the applied TED account places sleep, movement and nutrition within therapeutic planning (Mirea, 2025b). Practical questions include whether the person is sufficiently rested, whether the activity fits their capacity and whether training supports daily life or becomes another demand they feel compelled to meet.

Mireaโ€™s (2026) Pendulum-Effect account describes avoidance, overcompensation and capitulation as protective responses within a formulation concerned with shame. In training, these might appear as withdrawing when mistakes become visible, exercising punitively to prove worth or accepting an identity of permanent incapability. Embodied rehearsal offers a proposed way of practising a different response while difficult experience remains present.

This formulation helps distinguish occasions when demands should be reduced from occasions when a prediction maintaining avoidance could usefully be tested. Rest and adaptation may be appropriate on one occasion; on another, the useful learning may be that discomfort is compatible with chosen action.

Meichenbaumโ€™s Roadmap to Resilience places physical resources alongside interpersonal, emotional, cognitive, behavioural and spiritual resources (Meichenbaum, n.d.). This broader account keeps strengths, relationships and meaning visible alongside physical capability.

Matching movement to the individual

Activity selection begins with interests and circumstances. What has the person enjoyed previously? Would they prefer technical learning, rhythm, independent practice, cooperation or competition? What does a particular sport represent to them? Physical health, disability and previous injury matter alongside cultural identity, cost, transport and the available training environment.

The useful psychological question is often what the person needs an opportunity to practise. Achievable progression may help someone who expects failure. A supportive class may provide opportunities to be seen trying and receive feedback. Partner work might allow someone to express a preference, while regular shared activity may offer structure and repeated contact to someone experiencing isolation.

These possibilities do not prescribe a sport for a diagnosis. One person with social anxiety may appreciate interaction organised around a shared task; another may initially prefer predictable individual instruction. Someone seeking confidence may find a suitable opportunity in martial arts, dance, climbing or resistance training. Formulation clarifies what confidence means and how the setting might help develop it.

Personal meaning and enjoyment also matter for continuation. Teixeira et al. (2012) reviewed 66 studies of exercise through self-determination theory. Their findings supported relationships between autonomous motivation and participation, with enjoyment and intrinsic motivation particularly relevant to longer-term adherence. Much of the evidence was observational.

Interest may develop through skill, companionship or discovering that movement feels different from what was anticipated. Initial discomfort does not necessarily indicate a poor match, while persistent difficulty should remain open to review. Choosing another instructor, format or activity can be a successful outcome of collaborative planning.

Why martial arts may be a useful resource

Martial arts can bring technical learning, bodily effort and interpersonal negotiation into the same activity. Depending on the practice, participants must manage distance, coordinate movement, respond to another person and communicate the intensity they are willing to accept. These features can make questions of capability, control and boundaries immediately available for reflection.

Their significance remains individual. Someone who habitually withdraws may value discovering that they can take up space and act decisively. A person who overcompensates through excessive effort may benefit from practising restraint, accepting correction or stopping at an agreed point. Another may find predictable partner work an accessible route into cooperation and connection.

These are proposed learning opportunities. Their usefulness depends on preference, instruction and interpretation. The range of available formats also allows adaptation: individual non-contact practice, recreational group training and partner exercises need not involve the same demands.

The clinical rationale rests on the fit between these opportunities and the personโ€™s formulation. Martial practice becomes informative when it allows relevant responses to be practised and reviewed.

Confidence, shame and responses to mistakes

Confidence may develop through supported action. A simple movement becomes a short combination, and repetition makes progress visible. Someone expecting complete failure may discover that they can learn part of a task and return after difficulty.

Technical mastery, specific self-efficacy and global self-worth nevertheless remain distinguishable. A person can acquire skill while continuing to interpret mistakes as evidence of inadequacy. Shame and self-criticism therefore warrant attention when relevant to the formulation. Compassion-focused therapy provides one example of explicitly addressing these difficulties (Leaviss and Uttley, 2015).

Training offers frequent encounters with being inexperienced. Sequences are forgotten and coordination develops unevenly. A behavioural experiment could examine a prediction that an ordinary mistake will lead to rejection. It requires an agreed prediction, suitable practice and review of what happened, including the participantโ€™s interpretation and protective strategies.

Progression can vary through complexity, speed, effort or social visibility. These dimensions need not increase together. For someone whose worth depends on achievement, a useful task might involve receiving correction without self-attack or stopping at an agreed level.

Assertiveness can also be rehearsed through asking for clarification, requesting lighter contact or declining an additional round. The instructorโ€™s response becomes part of the learning. Physical performance provides only a partial account of progress when the intended change concerns communicating a need or recovering from a mistake.

Manageable challenge and coping rehearsal

Exertion, uncertainty and frustration can provide occasions to practise coping. The first challenge may be entering the venue; later tasks might involve an unfamiliar combination or remaining engaged after an error.

Meichenbaum and Deffenbacherโ€™s (1988) stress inoculation framework offers a useful structure: develop a shared understanding, acquire and rehearse coping skills, then apply and review them in relevant situations. This directs attention to preparation and coping choices before increasing demand.

Brief self-instructions such as โ€œslow the sequenceโ€, โ€œask for clarificationโ€ or โ€œreset and try againโ€ connect language with available actions. Hatzigeorgiadis et al. (2011) found that self-talk interventions improved sport performance. Their wider therapeutic contribution needs assessment against the intended clinical outcome.

Physical endurance, anxiety sensitivity and distress tolerance are distinct. LeBouthillier and Asmundson (2015) found that one aerobic exercise session reduced anxiety sensitivity without improving distress tolerance or intolerance of uncertainty. Their later four-week trial involving 48 participants reported benefits for distress tolerance and intolerance of uncertainty following resistance training (LeBouthillier and Asmundson, 2017). Different activities and doses may influence different processes.

Craske et al. (2014) emphasise expectancy violation and new learning within exposure rather than requiring fear to diminish during a session. Movement could provide a setting for such learning where a relevant fear has been identified. The task might examine whether activation can be experienced while retaining choice. Increased intensity alone is an inadequate measure of therapeutic progress.

Attention, flexibility and personal meaning

Movement sequences require attention to targets, balance, timing and instructions. A participant can notice distraction or self-criticism and return to the next action. This provides a concrete setting for attentional practice, with transfer beyond the task requiring review.

Acceptance and commitment therapy offers language for willingness, defusion and values-guided action. Macri and Rogge (2024) review psychological flexibility and inflexibility processes within ACT. Applied here, willingness might involve allowing embarrassment while trying a chosen task; defusion might involve noticing โ€œeveryone thinks I am uselessโ€ without treating it as an instruction to leave. Flexibility also includes adapting or declining when those choices serve the personโ€™s goals.

Dialectical behaviour therapy distinguishes mindfulness, emotion regulation, distress tolerance and interpersonal effectiveness (Chapman, 2006). These distinctions help specify whether a task concerns attending, modifying activation, enduring distress or communicating a need.

Absorption during training may provide welcome relief. Its function deserves review if movement becomes the only way to avoid painful thoughts. Psychological flexibility concerns the range of responses available, including the ability to rest and engage with difficulties elsewhere.

Meaning should likewise be elicited directly. Practice may represent cooperation, capability or community membership; it may also become organised around punishment or approval. Park (2010) distinguishes efforts to make meaning from meanings actually achieved. Attendance and enjoyment therefore provide incomplete evidence of changes in longstanding beliefs or identity.

Bodily activation, breathing and recovery

Training may make breath-holding, muscular bracing, fatigue and rising arousal more noticeable. A participant can practise adjusting effort, recognising tension and responding to changing demands.

Competition research demonstrates that these demands can be accompanied by substantial physiological activation. Slimani et al. (2018) identified increases in cortisol, adrenaline and noradrenaline following striking combat events compared with pre-combat measurements. These findings concern acute responses to competition and cannot establish how every recreational participant experiences training or whether participation produces lasting improvements in regulation.

Our observations suggest that increasing familiarity may sometimes be accompanied by less unnecessary tension, more economical movement and better-paced effort. We propose that this can provide a setting for learning to act purposefully while activated. This interpretation concerns observable responses; particular hormone or neurotransmitter levels cannot be inferred from performance.

Sometimes the useful task involves reducing unnecessary activation. At other times, it involves discovering that activation is tolerable. Instructions should fit the therapeutic purpose and physical demand.

Breathing during movement differs from a separate paced-breathing practice. Balban et al. (2023) examined brief daily structured breathing protocols, including cyclic sighing, and reported effects on mood and respiratory rate. Fincham et al. (2023) found that coherent breathing at approximately 5.5 breaths per minute did not outperform a matched 12-breaths-per-minute practice on mental health and wellbeing outcomes in 400 participants. These studies concern particular breathing protocols rather than breathing instructions during striking combinations.

During exertion, ventilation must accommodate physical demand. Recovery breathing can be explored separately and reviewed for whether it supports participation. A practice may become restrictive if the person concludes that discomfort must disappear before action is possible.

Recovery also concerns how a session ends, rest between training days and responses to fatigue. These observations help establish whether exercise supports wider functioning or becomes punitive. Recovery should remain adaptable rather than become another performance standard.

Belonging, coaching and interpersonal boundaries

A supportive club can offer repeated contact around shared activity. Connection may develop without immediate personal disclosure. Predictable routines, recognition and constructive feedback may make participation easier, depending on the interpersonal environment.

For people with histories of coercion or interpersonal threat, proximity, commands, touch or unpredictability may carry particular significance. Preparation should establish what participation involves, available adaptations and how consent can be withdrawn. An instructor who respects a request can support learning that needs may be expressed without rejection.

A first step may involve contacting an instructor, observing a class or trying a short introduction. Review should address experience and interpretation. Did the anticipated difficulty occur? Did assistance feel useful or become further evidence of inadequacy? Was there interest or enjoyment?

An unpleasant experience may justify another setting. It should not automatically be interpreted as avoidance to overcome. The suitability of the environment remains part of the formulation.

A hypothetical clinical illustration

The following illustration describes proposed professional reasoning rather than an actual patient account.

An adult interested in boxing avoids asking for help at work and expects that expressing a need will provoke irritation. They also stop unfamiliar activities after mistakes, interpreting difficulty as evidence of incompetence. Assessment explores physical health, previous learning experiences, the meaning of bodily activation and whether current relationships contain actual hostility. It identifies strengths, including an interest in technical skills and previous occasions of effective communication.

A shared hypothesis is that remaining silent provides immediate relief while preventing learning about how others respond to reasonable requests. The client chooses a short non-contact introduction with an instructor who welcomes adaptation. The proposed experiment concerns requesting a slower pace during a manageable combination.

Before practice, clinician and client specify the prediction and rehearse a credible request. Afterwards, review examines whether the request was made, how the instructor responded and how that response was interpreted. If a respectful response is dismissed as โ€œonly because this is therapyโ€, the interpretation becomes a question to investigate. A dismissive response would require reconsideration of both the prediction and the suitability of the setting.

An agreed experiment outside training might involve asking a colleague to clarify an instruction. Review would distinguish willingness, actual behaviour and confidence, which may change at different rates. The example shows how a chosen physical activity can provide a setting for testing a prediction and rehearsing agency.

Evaluating learning beyond training

Evaluation should match the formulation. Technical competence, specific self-efficacy, global self-worth, self-critical responding and everyday participation are related but distinct outcomes. Session review can record predictions, coping choices, interpretation and actual behaviour. Suitable symptom or wellbeing measures can complement personally meaningful goals.

Learning outside training requires further opportunities for practice. Someone who returns to a drill after an error might revisit an activity they previously abandoned. A participant who communicates a limit may examine where else expressing a preference matters. These are further experiments with outcomes to review.

Follow-up should examine whether changes persist, whether participation continues and what happens during interruptions. Attendance, adaptations, adverse experiences and discontinuation provide information about fit. Missed sessions and fluctuating energy should be anticipated within a realistic routine.

The clientโ€™s explanation should remain distinguishable from the clinicianโ€™s inference. Reported improvement is valuable information, while causal conclusions require stronger evidence.

Physical risk and professional responsibilities

Contact combat sports introduce injury exposures requiring explicit consideration. Head impacts and concussion are material concerns; the Association of Ringside Physicians has emphasised the particular demands of concussion management in this setting (Neidecker et al., 2019).

Non-contact practice can provide movement and learning opportunities without making head contact part of the therapeutic task, but it is not injury-free. Grappling, kicking and pad work place demands on joints, balance and physical capacity.

Selection and progression should account for health, previous injury and current capacity, with appropriate professional input where needed. Participation should permit stopping and distinguish ordinary effort from pain or symptoms requiring reassessment.

Psychotherapy and martial arts instruction require separate competencies. A clinician using physical tasks needs relevant competence and suitable arrangements, or collaboration with a qualified instructor. Clear roles, informed consent, confidentiality and agreed communication help participants understand what is offered.

Combining roles requires attention to whether the person feels free to disagree or stop. Information shared with an instructor should be limited to what is needed for agreed coordination and shared with the clientโ€™s consent.

Limitations and research priorities

This selective review combines heterogeneous exercise findings, discipline-specific research and conceptual accounts. Its source selection may omit relevant evidence, and it provides no pooled estimate or formal appraisal of the literature as a whole. Observations and individual experiences inform the clinical proposal but do not establish treatment effectiveness.

Smith and Merwin (2021) describe interacting biological and behavioural pathways through which exercise may influence mental health. General findings concerning cognition, inflammation or neuroplasticity cannot establish that a particular martial arts programme produces the same changes or that those changes explain clinical improvement.

A useful comparative question is whether explicit formulation-guided instruction adds benefit to otherwise similar physical practice. Research could compare matched programmes with and without agreed psychological tasks, accounting for encouragement, contact time, progression and expectations. Comparisons with other meaningful activities could examine shared contributions such as mastery and social connection.

Individualisation also deserves study. Does matching preferences and therapeutic goals improve engagement? Which features of instruction influence participation? When should the initial choice be revised?

Prospective assessment should measure intended outcomes and candidate processes over time. Changes in proposed mechanisms should precede the outcomes they are intended to explain, with alternative explanations considered.

Carefully planned single-case experimental designs may help investigate delivery before larger trials. Follow-up, concurrent care, practitioner competence and less favourable experiences should be reported. Including people who discontinue or find the activity unsuitable would improve understanding of practical limits.

Conclusion

The available evidence suggests that martial arts training can support mental health for some participants, although benefits vary across practices, populations and training environments. Its place within individualised care depends on what participation offers the particular person.

Martial arts bring physical activity, technical learning and interpersonal exchange together, creating opportunities to practise choice during manageable challenge. Therapeutic goals may concern developing confidence, responding differently to mistakes, communicating limits, coping with activation or reconnecting with others. Clinical usefulness depends on matching these opportunities to the personโ€™s formulation and reviewing what becomes available beyond training.

The wider exercise literature supports therapeutic relevance, while the specific outcomes and mechanisms of martial arts require further investigation. Our observations inform a clinical proposal: chosen and appropriately adapted practice may provide a setting in which people test expectations, develop agency and participate more fully in a life they value.

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About the Authors

Daniel Mirea is the founder of NeuroAffective-CBT, an accredited CBT therapist and a university lecturer. He is also a trained martial artist and a sports-psychotherapy consultant.

Chris People holds a black belt in traditional Japanese martial arts and teaching awards in combat sports and Brazilian martial arts. He trains both adults and children and is an accredited Hypno-CBT therapist and trainer. He is also undertaking training in psychotherapy.

Declaration of Interests and Article Scope

Daniel Mirea founded NeuroAffective-CBT, which provides a conceptual perspective discussed in this article. The clinical proposals draw partly on the authorsโ€™ observations and personal experiences of training. No original patient data are reported, and the clinical illustration is hypothetical.

Ketogenic Diet and Mental Health

Daniel Mirea (May, 2026)
|The NeuroAffective-CBTยฎ Journal | 

Could Altering Brain Metabolism Improve Emotional Wellbeing?

Abstract

This article explores the emerging fields of metabolic psychiatry and nutritional psychiatry, two rapidly developing areas of research investigating how metabolism, inflammation, insulin resistance, mitochondrial function, and nutrition may influence mental health and brain functioning. It examines the growing interest in ketogenic diets, originally developed in the 1920s as a treatment for epilepsy, as potential interventions capable of affecting mood, cognition, emotional regulation, and psychiatric symptoms through changes in brain energy metabolism.

The article also considers an important conceptual question: why are these developments increasingly discussed within psychiatry and medicine, yet far less frequently within mainstream psychology and psychotherapy? While nutritional psychiatry focuses upon the biological and medical relationship between diet and mental illness, psychological models have historically placed greater emphasis upon cognition, behaviour, trauma, attachment, and emotional learning. Emerging integrative approaches such as NeuroAffective-CBTยฎ (NA-CBTยฎ) attempt to bridge this divide by recognising that psychological functioning and physiological regulation continuously interact within the Bodyโ€“Brainโ€“Affect system.

Although research in this area remains in its early stages, increasing evidence suggests that mental health and metabolic health may be far more interconnected than previously understood.

The relationship between nutrition, metabolism, and mental health is increasingly recognised as one of the most important discussions within modern psychiatry and integrative psychotherapy.

Keywords:
Ketogenic diet; mental health; metabolic psychiatry; nutritional psychiatry; NeuroAffective-CBT; NA-CBT; brain metabolism; insulin resistance; mitochondrial dysfunction; emotional regulation; nutritional ketosis; psychotherapy; metabolism and mental health; inflammation; neuroplasticity; brain energy; metabolic health; depression; anxiety; bipolar disorder; ADHD; trauma; Bodyโ€“Brainโ€“Affect model.

Introduction: Exploring the Emerging Science of Metabolic Psychiatry

For decades, mental health treatment has focused primarily on psychotherapy and medication. These approaches remain incredibly important and, for many people, life-changing. However, a growing body of research is beginning to suggest that another major factor may have been underestimated for far too long:

Metabolic health.

Researchers working within the emerging field of metabolic psychiatry are increasingly exploring how brain energy, inflammation, insulin resistance, diet, and mitochondrial function may influence emotional wellbeing and psychiatric symptoms.

One of the most discussed interventions within this field is the ketogenic diet โ€” not simply as a weight-loss strategy, but as a possible way of improving how the brain produces and uses energy.

At its core, the idea is surprisingly simple:

Mental health and physical metabolism may be far more interconnected than we once believed.


What Is the Ketogenic Diet?

The ketogenic diet was originally developed in the 1920s as a medical treatment for severe epilepsy in children. Physicians had noticed that periods of fasting sometimes dramatically reduced seizures, but prolonged fasting was obviously not sustainable. Researchers therefore attempted to create a diet that could reproduce the metabolic effects of fasting while still allowing people to eat normally.

The result became known as the ketogenic diet.

A ketogenic diet significantly reduces carbohydrates while increasing fat intake and maintaining moderate protein levels. This shifts the body away from relying primarily on glucose (sugar) for energy and toward burning fat and producing molecules called ketones.

This metabolic state is known as nutritional ketosis.

Ketones can act as an alternative fuel source for the brain, and many researchers now believe that this change in fuel supply may affect not only physical health, but also emotional and cognitive functioning.

In simple terms, a ketogenic diet is a low-carbohydrate, moderate-protein, high-fat nutritional approach designed to shift the body away from relying primarily on glucose (sugar) for energy and toward producing ketones as an alternative fuel source. Ketones are molecules produced by the liver through the breakdown of fat and can be used by the brain and body for energy.

In practical terms, ketogenic diets typically encourage foods such as oily fish, eggs, olive oil, avocado, nuts, seeds, natural full-fat dairy products, and unprocessed meats, while reducing foods high in sugar and refined carbohydrates such as sweets, sugary drinks, white bread, pastries, ultra-processed snacks, and heavily processed fast foods. Many clinicians and researchers also emphasise the importance of prioritising healthier fats and minimally processed foods rather than simply consuming large amounts of fat indiscriminately.

Therefore ketogenic diets are not about proteins over everything else. Protein intake on a ketogenic diet is generally calculated according to body weight rather than height. The formula is rather simple:

Protein (g/day) = Body Weight (Kg) ร— 1.2โ€“1.75

Where:

โž” 1.2 g/kg = Sedentary individuals

โž” 1.4โ€“1.6 g/kg = Most adults following a ketogenic diet

โž” 1.75 g/kg = Physically active individuals, older adults, or those seeking to preserve lean muscle mass

Example:

An individual weighing 80 kg would require:

80 kg ร— 1.2 = 96 g protein/day

to

80 kg ร— 1.75 = 140 g protein/day

Therefore, a daily protein intake of approximately 96โ€“140 g of protein would be appropriate.

For individuals who are significantly overweight or obese, protein requirements may be calculated using ideal body weight or estimated lean body mass rather than total body weight.

Importantly, ketogenic diets are not high-protein diets. Therapeutic ketogenic approaches are typically characterised as high-fat, moderate-protein, and very-low-carbohydrate diets, with protein intake maintained at levels sufficient to preserve muscle mass while supporting nutritional ketosis.


The Forgotten Medical History of Keto

Although ketogenic diets have become fashionable in recent years, their origins are deeply medical rather than commercial.

The ketogenic diet was first formally introduced in 1921 at the Mayo Clinic by Dr. Russell Wilder. At the time, it was considered a serious neurological treatment rather than a lifestyle trend.

Throughout the 1920s and 1930s, ketogenic diets were widely used in hospitals to treat epilepsy, often with remarkable results. Interest later declined after anti-seizure medications became available in the 1940s and 1950s, largely because medication was easier to prescribe and commercially scalable.

For decades, ketogenic therapy remained mostly confined to treatment-resistant epilepsy.

Only in the past twenty years has scientific interest expanded again. Researchers are now exploring ketogenic and low-carbohydrate approaches in relation to obesity, insulin resistance, type 2 diabetes, Alzheimerโ€™s disease, Parkinsonโ€™s disease, migraine disorders, inflammation, and increasingly, mental health conditions such as depression, bipolar disorder, schizophrenia, anxiety disorders, and ADHD.

This newer field, more established in the United States than in the United Kingdom, is often referred to as metabolic psychiatry, a field that has emerged more recently than nutritional psychiatry. Using modern neuroscience and advances in brain metabolism research, it is beginning to revisit an old question:

Could changing brain metabolism influence mental health outcomes?


The Brain Is an Energy-Hungry Organ

The human brain represents only around 2% of total body weight, yet it consumes roughly 20% of the bodyโ€™s energy at rest.

In simple terms, the brain is extraordinarily energy-demanding.

Increasingly, researchers suspect that many psychiatric and neurological conditions may involve problems with how the brain produces, accesses, or regulates energy. Scientists are investigating links between mental illness and insulin resistance, inflammation, oxidative stress, mitochondrial dysfunction, and disrupted neurotransmitter regulation.

This has led to an important question:

What happens when the brain is not being fuelled efficiently?

Some researchers now believe that certain psychiatric symptoms may partly reflect a โ€œbrain energy crisisโ€ occurring at the cellular level.


โ€œChanging the Brainโ€™s Operating Systemโ€

Harvard psychiatrist Chris Palmer has described the ketogenic diet as potentially changing the brainโ€™s โ€œoperating system.โ€

When the body moves away from a high-carbohydrate, high-insulin state and begins using ketones for fuel, brain cells appear to function differently. Researchers believe this metabolic shift may influence inflammation, neurotransmitter balance, oxidative stress, hormone regulation, and mitochondrial function.

Some scientists hypothesise that ketones may provide a more stable and efficient fuel source for certain brain cells, potentially improving energy production while reducing inflammatory stress.

Although the science is still evolving, this may help explain why some individuals report improvements not only in weight or energy levels, but also in mood stability, concentration, emotional regulation, and mental clarity.


Mental Health and Metabolic Dysfunction

Modern psychiatry is increasingly recognising that mental health difficulties are not always โ€œjust psychological.โ€

Large studies have repeatedly found strong associations between psychiatric conditions and metabolic problems such as obesity, insulin resistance, metabolic syndrome, inflammation, and type 2 diabetes.

This does not mean that depression, anxiety, bipolar disorder, ADHD, PTSD, or schizophrenia are โ€œcaused by diet.โ€ Mental health is always complex and multi-layered. Trauma, relationships, stress, genetics, attachment history, and social environment all matter enormously.

However, biology matters too.

In fact, poor metabolic health may sometimes worsen emotional regulation, cognitive function, fatigue, motivation, sleep quality, and stress resilience. To complicate matters further, many psychiatric medications themselves can contribute to weight gain, insulin resistance, and metabolic dysfunction.

Whilst much of the emerging ketogenic psychiatry literature has focused upon symptom reduction, an equally important question may be whether metabolic interventions influence a person’s ability to engage with psychotherapy itself. This issue is particularly relevant within NeuroAffective-CBT (NA-CBT), where emotional regulation, cognitive flexibility, behavioural activation, and trauma processing are understood as dependent upon the ongoing interaction between physiology, affect, and cognition within the Bodyโ€“Brainโ€“Affect system.


Ketogenic Diets and Psychotherapy Engagement: A NeuroAffective-CBT Perspective

Recent work by Laurent (2026) has proposed an important conceptual shift in how ketogenic metabolic therapy (KMT) may be understood within mental health services. Rather than focusing solely on whether ketogenic interventions directly reduce psychiatric symptoms, Laurent suggests that an equally important question is whether metabolic stabilisation may improve a person’s capacity to engage with psychotherapy itself.

Writing specifically about Cognitive Behavioural Therapy for Psychosis (CBTp), Laurent highlights that many individuals struggle to fully participate in treatment because of factors such as sleep disturbance, cognitive overload, emotional reactivity, poor concentration, low distress tolerance, fluctuating motivation, and difficulties completing between-session therapeutic tasks. These barriers often interfere with treatment initiation, retention, and successful completion.

As Laurent explains:

“The question of this paper is not whether ketogenic therapies are an effective treatment for schizophrenia spectrum disorders. The question is whether this can improve the ability for these patients to utilise CBTp.“

This distinction is clinically significant because it shifts attention from symptom reduction alone towards the broader issue of therapeutic readiness and engagement. Rather than asking whether ketogenic metabolic therapy directly treats psychosis, Laurent asks whether improvements in physiological functioning may help individuals engage more effectively in the psychological work required for meaningful change.

During discussion of the paper, Laurent further observed:

“Could some of the treatment benefits that people are reporting map onto what patients talk about when they discuss having difficulty using CBT?“

This question closely mirrors one of the central assumptions underpinning NeuroAffective-CBT: that psychological change is influenced not only by what individuals think, but also by the physiological state from which those thoughts emerge. Improvements in sleep quality, energy regulation, metabolic functioning, emotional stability, and cognitive clarity may influence therapeutic outcomes not merely through symptom reduction, but by enhancing a person’s capacity to engage in emotional learning, behavioural change, cognitive restructuring, trauma processing, and the development of an integrated sense of self.

Within NA-CBT, therapeutic progress is not viewed solely as a product of cognitive insight. Psychological functioning is understood as emerging from the continuous interaction between physiological regulation, emotional processing, and cognitive interpretation, as illustrated within the Bodyโ€“Brainโ€“Affect Triangle. From this perspective, interventions that improve physiological stability may indirectly strengthen psychotherapy by creating the conditions necessary for reflective thinking, emotional regulation, behavioural activation, and psychological resilience.

Laurent identifies several domains repeatedly reported within the ketogenic psychiatry literature that are also recognised barriers to successful psychotherapy engagement:

  • Sleep disturbance
  • Cognitive burden and “brain fog”
  • Emotional distress reactivity
  • Mood instability
  • Reduced resilience
  • Functional impairment in everyday life

These domains overlap considerably with those addressed within the original NeuroAffective-CBTยฎ TED model (Tirednessโ€“Exerciseโ€“Diet), where physiological regulation is viewed as a prerequisite for optimal emotional and cognitive functioning.

This observation is particularly noteworthy because the original TED model was developed long before the recent emergence of metabolic psychiatry. TED was originally conceived as a practical psychoeducational framework helping clients understand how tiredness, physical activity, nutrition, and lifestyle behaviours continuously influence emotional regulation, cognitive functioning, decision-making, and psychological resilience. From an NA-CBTยฎ perspective, physiological dysregulation frequently manifests as emotional volatility, cognitive overload, reduced distress tolerance, motivational difficulties, and increased vulnerability to shame-based coping patterns. The emerging ketogenic psychiatry literature may therefore be viewed as supporting a broader principle already embedded within the TED framework: when physiology becomes more stable, emotional regulation improves, cognitive flexibility increases, and psychological change often becomes more accessible.

From an NA-CBT perspective, ketogenic interventions should not be viewed as replacements for psychotherapy. Rather, where clinically appropriate and medically supervised, they may function as adjunctive interventions that enhance readiness for psychological treatment. In other words, metabolic interventions may help prepare the psychological and physiological conditions in which psychotherapy can take root and flourish.

This perspective is consistent with a broader biopsychosocial understanding of mental health. When physiological dysregulation is reduced, individuals often experience improved concentration, greater emotional tolerance, increased motivation, enhanced self-reflective capacity, and greater resilience in the face of distress. These changes may allow them to engage more effectively with cognitive restructuring, behavioural experiments, trauma processing, emotional regulation work, and other psychotherapy interventions.

Future research will be needed to determine the extent to which ketogenic metabolic therapy improves psychotherapy engagement across a range of mental health conditions. Nevertheless, the emerging evidence reinforces an important principle already embedded within the NeuroAffective-CBT framework: sustainable psychological change is often easier to achieve when physiological regulation is addressed alongside emotional and cognitive processes. Put simply, when the body functions more effectively, the mind is often better positioned to learn, adapt, regulate, and heal.

Within the NeuroAffective-CBT Bodyโ€“Brainโ€“Affect Triangle, physiological regulation, emotional experience, and cognitive processing are viewed as continuously interacting components of a single integrated system. Changes in sleep quality, nutrition, inflammation, insulin sensitivity, hormonal balance, physical activity, and energy metabolism do not simply affect the body; they may also influence how emotions are experienced, how meaning is constructed, and how individuals respond to psychological challenges.

From this perspective, ketogenic metabolic therapy represents one example of a broader principle that has long been embedded within the NA-CBT framework: psychological functioning cannot be fully separated from physiological functioning. The way we think, feel, regulate emotions, tolerate distress, and engage in psychotherapy is influenced not only by our beliefs, learning history, and relationships, but also by the biological state of the nervous system from which those experiences emerge.

Consequently, interventions that improve physiological regulation may indirectly enhance emotional resilience, cognitive flexibility, distress tolerance, self-reflective capacity, and therapeutic engagement. From a NeuroAffective-CBT perspective, physiology and psychology are not separate domains competing for explanatory power; rather, they represent different levels of the same interconnected human system. The Bodyโ€“Brainโ€“Affect Triangle therefore provides a framework for understanding how changes in metabolism, sleep, nutrition, physical activity, emotional regulation, cognition, behaviour, and relationships continuously influence one another. In this context, ketogenic metabolic therapy may be viewed not simply as a dietary intervention, but as one potential pathway through which physiological stabilisation may facilitate emotional regulation, psychological growth, and meaningful therapeutic change.


Clinical Implications for NeuroAffective-CBT

As discussed previously in the article TED Series, Part II: Insulin Resistance and Mental Health, insulin resistance may influence far more than blood sugar alone. Emerging evidence suggests it may also contribute to fatigue, emotional instability, cognitive slowing, cravings, depressive symptoms, and motivational collapse.

Within the NeuroAffective-CBT framework, these physiological states are understood as directly influencing the Bodyโ€“Brainโ€“Affect system central to emotional functioning.

From this perspective, ketogenic diets may hold psychotherapeutic relevance because they target metabolic flexibility and glucose regulation. By reducing glucose volatility and lowering insulin demand, ketogenic interventions may help stabilise energy availability within the brain and nervous system.

In everyday clinical terms, this may mean that some individuals feel calmer, clearer, less reactive, more emotionally stable, and more capable of engaging in therapeutic work.

Within NA-CBT, TED interventions (Tiredโ€“Exerciseโ€“Diet) are not presented as rigid dietary rules or wellness ideology. Rather, they are viewed as biologically informed interventions that may improve emotional regulation capacity and psychotherapy responsiveness.

When individuals experience chronic fatigue, emotional dysregulation, shame-driven eating, unstable sleep, poor concentration, or constant cravings, psychotherapy itself may become significantly more difficult because the nervous system remains physiologically overwhelmed.

Chronic physiological dysregulation may also increase vulnerability to shame-based interpretations of failure, weakness, inadequacy, and self-criticism, further reinforcing the maladaptive cycles described within the Pendulum Effect model of NeuroAffective-CBT.

Improving metabolic stability may therefore increase a personโ€™s ability to tolerate emotions, engage in trauma processing, participate in behavioural activation, and benefit from cognitive restructuring.

Importantly, NA-CBT does not present ketogenic diets as a miracle cure or replacement for psychotherapy, psychiatric care, or medication. Rather, the model proposes that psychological functioning and physiological functioning continuously interact.

The brain does not operate separately from the body.

Emotional suffering is often both psychological and physiological at the same time.


Final Thoughts

The ketogenic diet is not a universal solution, and the science surrounding metabolic psychiatry remains in its early stages. Much more high-quality research is still needed, particularly regarding long-term outcomes, individual differences, and the interaction between nutrition, metabolism, psychotherapy, and psychiatric care.

However, one of the most important developments emerging from both metabolic psychiatry and nutritional psychiatry may be the growing recognition that mental health cannot be fully separated from physical health.

What we eat influences how we think, feel, regulate emotion, tolerate stress, and engage with the world around us. Brain metabolism, inflammation, insulin resistance, sleep, trauma, lifestyle, and emotional learning may all interact far more dynamically than traditional models once assumed.

At the same time, these developments raise important questions for psychology and psychotherapy. If nutrition and metabolism can influence mood, cognition, motivation, emotional regulation, and neuroplasticity, then psychological therapies may also benefit from greater integration with physiology and lifestyle medicine.

Approaches such as NeuroAffective-CBT (NA-CBT) attempt to bridge this divide by recognising that the brain does not operate separately from the body, and emotional suffering is often simultaneously psychological, neurological, behavioural, and physiological.

Rather than viewing biology and psychology as competing explanations, emerging integrative models increasingly suggest they may represent different levels of the same human system.

The future of mental health treatment may therefore lie not in choosing between biology or psychology, but in understanding how physiology, emotion, cognition, behaviour, relationships, trauma, and meaning continuously interact within one integrated human system. From a NeuroAffective-CBT perspective, lasting psychological change becomes most achievable when the Body, Brain, and Affect are understood not as separate domains, but as interconnected components of the same human experience.


Disclaimer

This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Ketogenic diets and therapeutic nutritional ketosis may significantly affect metabolism, medications, blood sugar, blood pressure, and psychiatric symptoms. Individuals considering significant dietary changes, particularly those with mental health conditions, eating disorders, diabetes, or those taking medication, should consult appropriately qualified healthcare professionals before making changes to diet or treatment plans.


References

Chris Palmer (2022). Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health โ€” and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More. BenBella Books.

Georgia Ede (2024). Change Your Diet, Change Your Mind. London: Hodder & Stoughton.

Laurent, N. (2026) ‘Ketogenic metabolic therapy as a candidate adjunct for CBTp delivery in schizophrenia spectrum disorders’, Frontiers in Psychology, 17, 1775511. doi:10.3389/fpsyg.2026.1775511.

Mirea, D. (2025) TED in NeuroAffective-CBTยฎ: An applied self-regulation framework for enhancing emotional well-being through sleep, movement and nutrition. NeuroAffective-CBTยฎ. Available at: https://neuroaffectivecbt.com/2025/12/10/ted-in-neuroaffective-cbt-an-applied-self-regulation-framework-for-enhancing-emotional-well-being-through-sleep-movement-and-nutrition/ (Accessed: 2026).

Russell Wilder (1921). Original work introducing the ketogenic diet as a treatment for epilepsy at the Mayo Clinic.

Further Reading

Articles exploring NeuroAffective-CBTยฎ, emotional regulation, trauma, neuroplasticity, and the Bodyโ€“Brainโ€“Affect model. And additional perspectives integrating physiology and psychotherapy can be found at NeuroAffective-CBTยฎ Articles including: TED Series, Part II: Insulin Resistance and Mental Health

Research literature within Metabolic Psychiatry exploring the relationship between brain energy metabolism, insulin resistance, inflammation, and psychiatric disorders.

Mitochondrial Psychiatry literature investigating the role of mitochondrial dysfunction in depression, bipolar disorder, schizophrenia, and neurodegenerative conditions.

Research into insulin resistance and mental health increasingly suggests associations between impaired glucose metabolism, inflammation, depression, cognitive dysfunction, and emotional dysregulation.

Studies investigating ketogenic therapy in epilepsy continue to demonstrate the long-established neurological effects of nutritional ketosis, particularly in treatment-resistant epilepsy.

Evidence supporting ketogenic diet as an adjunct therapy in the treatment for chronic mental illness: 

MetabolicMind.org

Frontiers | Ketogenic metabolic therapy as a candidate adjunct for CBTp delivery in schizophrenia spectrum disorders

A NeuroAffective-CBT Perspective on Perimenopause: Multi-System Recalibration of Brain, Body, and Behaviour

Daniel Mirea (April, 2026)
|The NeuroAffective-CBTยฎ Journal |ย 

Defining Perimenopause and Menopause

Perimenopause is often approached primarily as a hormonal issue and is typically managed within general medical practice. While this is appropriate, it may underrepresent the broader impact of this transition across neural, behavioural, and regulatory systems. As a result, the condition is not consistently addressed within the field of psychotherapy. From a NeuroAffective-CBT perspective, perimenopause can be understood as a multi-system recalibration involving the brain, body, and behaviour, with direct implications for clinical formulation and support.

Perimenopause refers to the transitional period leading up to menopause, during which ovarian hormone production becomes increasingly variable. This phase may begin several years before the final menstrual period and is characterised by fluctuations in estrogen and progesterone levels, often accompanied by changes in menstrual regularity, sleep, mood, and physiological stability.

Menopause is clinically defined as the point at which menstruation has ceased for twelve consecutive months, marking the end of reproductive function (National Institute for Health and Care Excellence, 2024). Postmenopause refers to the phase following this transition, during which hormone levels stabilise at a lower baseline.

From a physiological perspective, perimenopause represents a continuous process of endocrine adjustment rather than a discrete event. It is characterised by fluctuating hormone levels and associated changes in sleep, mood, and cognitive function (National Institute for Health and Care Excellence, 2024). From a NeuroAffective-CBT perspective, this transition can be understood as a biopsychophysiological process in which these changes increase regulatory load across multiple interacting systems.

The transition from the reproductive years into this phase involves a significant endocrine shift, characterised primarily by declining estrogen and progesterone levels (Mirea and Popa, 2026). These hormonal changes do not affect a single system in isolation. Estrogen receptors are widely distributed across the brain, cardiovascular tissue, skeletal muscle, bone, and immune structures, meaning that changes in estrogen signalling influence multiple interconnected physiological systems simultaneously (Strasser, 2015; Mennitti et al., 2024).


Brain and Neurochemical Regulation

The central nervous system is directly involved in this transition. Estrogen crosses the bloodโ€“brain barrier and modulates neural function through its effects on receptor expression, synaptic plasticity, and neurotransmitter dynamics. In particular, estrogen interacts with serotonergic pathways, influencing serotonin synthesis, receptor sensitivity, and reuptake processes.

Fluctuations or sustained reductions in estrogen during perimenopause and menopause have been associated with changes in mood stability, increased vulnerability to anxiety, reduced cognitive clarity, and the commonly reported experience of โ€œbrain fog.โ€ These outcomes are multifactorial; however, altered stress responsivity and changes in neuroplastic processes are recognised contributors to emotional and cognitive shifts (Davidson and McEwen, 2012; Deslandes, 2014).


Gutโ€“Brainโ€“Immune Interactions

Serotonin regulation is not confined to the brain. Approximately 90% of serotonin is synthesised in the gastrointestinal tract. Although peripheral serotonin does not directly cross the bloodโ€“brain barrier, the gut microbiome influences central nervous system function through immune signalling, vagal pathways, and metabolite production, a bidirectional system often described as the gutโ€“brain axis.

Emerging evidence suggests further interaction between estrogen metabolism and the gut microbiome via the estrobolome, the collection of microbial genes capable of metabolising estrogens (Plottel and Blaser, 2011). After hepatic processing, conjugated estrogens enter the intestinal tract, where microbial enzymes may influence their reactivation and recirculation.

In parallel, short-chain fatty acids (SCFAs), produced by specific bacterial populations, contribute to gut barrier integrity, immune modulation, and metabolic regulation. During perimenopause, shifts in estrogen levels may coincide with changes in microbiome composition, with potential downstream effects on inflammatory tone and stress-related physiology (Gleeson et al., 2011; Nieman, 2018).


A System in Ongoing Dialogue

Taken together, endocrine, neural, immune, and microbial systems operate in continuous interaction. When estrogen signalling declines, the balance of regulatory processes across these systems may shift, influencing metabolic health, mood stability, energy regulation, and cognitive clarity.

From this perspective, the experience of perimenopause is not reducible to a single mechanism. Rather, it reflects the convergence of multiple regulatory changes occurring simultaneously across the organism.


NA-CBT Implications: Supporting Regulation During Transition

The day-to-day manifestations of this recalibration are both physiological and psychological. Changes in sleep quality, stress tolerance, digestion, appetite, mood stability, and cognitive function may reflect underlying shifts in hormonal, neural, and gutโ€“brain signalling; presenting complaints are common across a range of psychiatric conditions therefore diagnosis and mental health assessment is difficult.

Within the NA-CBT framework, these changes are understood not simply as symptoms to be eliminated, but as indicators of altered regulatory load within the system.

This perspective reinforces the importance of stabilising core regulatory domains:

  • Sleep: maintaining consistent timing and protecting recovery
  • Exercise: particularly resistance training, to support neuromuscular and metabolic stability
  • Nutrition: ensuring adequate protein, fibre, alcohol reduction and energy availability
  • Stress regulation: supporting transitions between activation and recovery

These are not quick fixes. They function as foundational supports for a system undergoing biological recalibration.


The Bodyโ€“Brainโ€“Affect Relationship

As outlined above, the bodyโ€“brainโ€“affect connection is central to how the organism functions as an integrated system. Early work by Charles Darwin (1872) recognised that affective expression is a core feature of emotional states and contributes to subjective experience. More recent research, including work by David J. Anderson (2014 and 2016), has further explored the neural circuits underlying behavioural responses, demonstrating how hormones and neuromodulators shape contextual affective states through signals experienced as feelings, imagery, and automatic behavioural tendencies.

From this perspective, the perimenopausal transition can be understood as a complex interaction of hormonal change, affective fluctuation, and behavioural shifts. Translating these processes into psychotherapy highlights the importance of understanding how to support exposure, regulation, and recovery in a safe and compassionate manner, with the aim of improving quality of life.

As illustrated in the Bodyโ€“Brainโ€“Affect model, this relationship provides a clinically useful framework for formulation:

  • Physiological states shape emotional and cognitive processes
  • Emotions influence thoughts and behaviour
  • Thoughts and behaviours, in turn, reshape physiology

Within this system, the TED model (Tired โ€“ Exercise โ€“ Diet) functions as the physiological regulation arm of NA-CBT, reducing background volatility so that deeper psychological learning can occur.

A central therapeutic aim is supporting clients in distinguishing between:

  • Raw affect โ€” the bodyโ€™s immediate signal of threat or discomfort
  • Interpretation โ€” the meaning the mind assigns to that signal

When these become fused, emotions may be experienced as overwhelming, self-defining, or difficult to regulate. Stabilising physiological state first helps create the conditions for more flexible interpretation and response.


Why Lifestyle Interventions Belong Inside Psychotherapy

When sleep is disrupted, movement is limited, or metabolic stability is compromised, individuals often experience:

  • heightened anxiety or irritability
  • increased emotional reactivity and rumination
  • intensified self-criticism or shame
  • reduced tolerance for uncertainty, stress, or interpersonal challenge

From an NA-CBT perspective, these are not failures of insight or willpower. They reflect a system operating under strain and psychotherapeutic intervention without emotional recalibration is difficult. The TED model aims for sufficiency rather than optimisation. The goal is not perfect habits, but a stable internal environment that reduces threat sensitivity and supports emotional regulation.


Illustrative Case Example

A 47-year-old woman presented with anxiety and work-related stress, without initial awareness of potential perimenopausal influences. A previous contact with mental health services had led to a referral for attention-deficit/hyperactivity disorder (ADHD), which was not subsequently supported. During assessment, she noted that her most intense episodes of worry occurred in the late morning, typically following poor sleep, skipped breakfast, and increased caffeine and sugar intake.

Using a TED-informed framework, these episodes were reformulated as reflecting not only psychological stress but also fatigue and metabolic instability. Initial intervention focused on stabilising these domains: sleep training, reducing caffeine and sugar intake, improving nutritional adequacy (including micronutrient support where indicated), and introducing a consistent routine of exercise, relaxation, and recovery practices.

As physiological stability improved, the client was better able to engage in psychological work, including exploring beliefs related to menopause, health, and identity. Subsequent consultation with her GP led to the initiation of hormone replacement therapy (HRT), which further contributed to improvements in overall quality of life. What initially felt overwhelming became more manageable as the underlying regulatory load was reduced. This case illustrates how addressing physiological load may facilitate engagement with psychological processes during the perimenopausal transition


Common Negative Beliefs and Associated Behavioural Patterns

The menopausal transition is often accompanied by shifts in the interpretation of internal states and significant alterations to self-image. A long history of mental illness complicates the picture even more. The following beliefโ€“affectโ€“behaviour patterns are commonly observed:

  1. โ€œSomething is wrong with meโ€
    Affect: anxiety, confusion, hypervigilance
    Behaviour: symptom checking, excessive reassurance seeking, or avoidance of medical consultation
  2. โ€œIโ€™m losing control of my body and mindโ€
    Affect: fear, helplessness
    Behaviour: withdrawal from demands, reduced decision-making, disengagement from responsibilities
  3. โ€œI canโ€™t cope like I used to. This is embarrassing; Sex is not the same. I will end up aloneโ€
    Affect: shame, frustration
    Behaviour: avoidance of challenge, argumentative, over-reliance on others, reduced role engagement
  4. โ€œThis is permanent and will only get worseโ€
    Affect: hopelessness
    Behaviour: reduced help-seeking, disengagement from treatment or behavioural change
  5. โ€œIโ€™m becoming less capableโ€
    Affect: self-doubt, embarrassment
    Behaviour: avoidance of cognitively demanding or evaluative situations
  6. โ€œIโ€™m not myself anymoreโ€
    Affect: identity disturbance, grief
    Behaviour: social withdrawal, loss of engagement in valued activities
  7. โ€œOther people will notice and judge meโ€
    Affect: social anxiety
    Behaviour: avoidance of visibility (meetings, presentations, social interaction)
  8. โ€œExercise will make things worse. Iโ€™m too exhaustedโ€
    Affect: fatigue, apprehension
    Behaviour: inactivity, loss of routine, reduced exposure to beneficial physiological stress
  9. โ€œI just need to push through thisโ€
    Affect: internal pressure
    Behaviour: paradoxical avoidance of rest and recovery, leading to further dysregulation
  10. โ€œI should be able to handle this on my ownโ€
    Affect: isolation, self-criticism
    Behaviour: reduced help-seeking (medical, psychological, or social)

NA-CBT Formulation

From a NeuroAffective-CBT perspective, these patterns often emerge when physiological signals (raw affect) become fused with cognitive interpretation.

For example:

Physiological load โ†’
Fatigue and hormonal fluctuation โ†’
Increased limbic (amygdala) reactivity โ†’
Threat-focused attention and cognitive interpretation (โ€œIโ€™m losing controlโ€) โ†’
Avoidance / compensatory / capitulatory behaviours โ†’
Reduced regulatory capacity โ†’
Increased instability โ†’
Increased physiological load

This sequence operates as a self-reinforcing loop. Behavioural responses such as avoidance, overcompensation, or capitulation may reduce distress in the short term, but they contribute to the maintenance of the problem through several interacting mechanisms.

First, they reinforce threat perception and amplify raw affect. When internal states are repeatedly interpreted as dangerous or unmanageable, the nervous system becomes increasingly sensitised, heightening vigilance toward bodily sensations and emotional shifts.

Second, they reduce exposure to corrective experiences. Avoiding situations, sensations, or demands limits opportunities to learn that these internal states are tolerable, transient, and manageable. As a result, threat-based interpretations remain unchallenged.

Third, these behaviours constrain opportunities for physiological regulation. Reduced movement, disrupted routines, poor sleep, and inconsistent nutrition can increase physiological load, narrowing the systemโ€™s capacity to recover from activation.

Over time, these processes interact to maintain both physiological and psychological dysregulation. Increased instability feeds back into elevated physiological load, perpetuating the cycle and increasing the likelihood that future internal states will again be interpreted as threatening.

Intervention within this framework focuses on interrupting this loop by stabilising physiological load, modifying threat-based interpretation, and reintroducing corrective behavioural experience.


Clinical Implications

The therapeutic aim is not the immediate elimination of these beliefs, but the creation of conditions in which they can be re-evaluated more flexibly.

This involves:

  • differentiating physiological state from interpretation
  • stabilising underlying regulatory systems (TED: sleep, exercise, nutrition)
  • gradually reintroducing avoided or restricted behaviours

As regulatory stability improves, interpretation becomes less rigid and more context-sensitive. This supports a shift from:

โ€œSomething is wrong with meโ€
to
โ€œMy system is under load, and can be supportedโ€


Plain-Language Summary

Perimenopause is not just hormonal; it affects the whole system โ€” brain, body, and behaviour.

Hormonal changes influence mood, sleep, stress sensitivity, and cognitive clarity. At the same time, the brain, immune system, and gut interact in ways that shape how these changes are experienced.

From a NeuroAffective-CBT perspective, these are not simply โ€œsymptomsโ€, but signals that the system is operating under increased regulatory load. By supporting sleep, movement, and nutrition, individuals can reduce this load and improve emotional regulation. These lifestyle interventions can then be complemented by targeted cognitive and behavioural strategies.

Rather than being only a period of disruption, perimenopause can also represent an opportunity to develop more stable and adaptive patterns of functioning, adjust expectations, and strengthen coping and self-efficacy in preparation for the next stage of transition.


Conclusion

Perimenopause can be understood as a period of multi-system adjustment involving endocrine, neural, immune, and metabolic processes. The variability in individual experience reflects the complexity of these interacting systems rather than a single causal pathway.

From a NeuroAffective-CBT perspective, this transition highlights the importance of integrating physiological regulation into psychological formulation. Changes in mood, cognition, and behaviour are not solely psychological in origin, but often reflect shifts in underlying regulatory systems operating under increased load.

This perspective has practical implications. Interventions that stabilise sleep, support nutritional adequacy, and maintain appropriate levels of physical activity may help reduce background physiological volatility, creating conditions in which emotional regulation and cognitive flexibility can be more effectively supported.

Within this framework, the aim is not to eliminate distress, but to improve the systemโ€™s capacity to move between states of activation and recovery with greater stability and predictability. As regulatory capacity improves, individuals are better able to differentiate between physiological signals and their interpretation, reducing the likelihood that transient internal states are experienced as overwhelming or self-defining.

In this way, perimenopause can be understood not only as a period of challenge, but also as an opportunity for recalibration. When supported appropriately, this transition may facilitate the development of more stable regulatory patterns across physiological and psychological domains, contributing to long-term resilience and adaptive functioning.

Perimenopause is not merely an endocrine event but a biopsychophysiological transition with implications for affect regulation, cognition, sleep, and behaviour. A NeuroAffective-CBT formulation may be clinically useful insofar as it integrates physiological state, emotional processing, and behavioural adaptation. Within this framework, interventions targeting sleep regularity, movement, nutrition, stress recovery, and cognitive appraisal may help reduce regulatory load and support more flexible functioning during the menopausal transition. However, the specific contribution of NA-CBT remains a clinical formulation model rather than an established evidence-based treatment protocol for perimenopausal distress.


Glossary of Key Terms

Perimenopause
The transitional phase before menopause, characterised by fluctuating levels of estrogen and progesterone, often accompanied by changes in mood, sleep, and physiological stability.

Menopause
The point at which menstruation has ceased for twelve consecutive months, marking the end of reproductive function.

Estrogen
A primary female sex hormone involved in reproductive function, but also influencing brain activity, mood regulation, bone health, and metabolic processes.

Serotonergic signalling
The activity of serotonin (a neurotransmitter) in the brain, involved in mood, emotional regulation, sleep, and cognition.

Synaptic plasticity
The brainโ€™s ability to change and adapt by strengthening or weakening connections between neurons, supporting learning, memory, and emotional regulation.

Stress responsivity
The way the body and brain respond to stress, including activation of hormonal and nervous system pathways.

Gutโ€“brain axis
The bidirectional communication system between the gastrointestinal tract and the brain, involving neural, immune, and metabolic pathways.

Estrobolome
The collection of gut bacteria capable of metabolising estrogen, influencing how estrogen is processed and recirculated in the body.

Short-chain fatty acids (SCFAs)
Metabolic by-products produced by gut bacteria that support immune function, gut integrity, and metabolic regulation.

Physiological load
The overall burden placed on the bodyโ€™s regulatory systems, influenced by factors such as sleep, stress, nutrition, hormonal changes, and physical activity.

Raw affect
Immediate, pre-cognitive bodily signals of emotional or physiological states (e.g., tension, fatigue, heat, agitation).

Cognitive interpretation
The meaning or explanation the mind assigns to internal or external experiences (e.g., โ€œsomething is wrong with meโ€).

Limbic (amygdala) reactivity
Increased activity in brain regions involved in threat detection and emotional processing, particularly the amygdala.

Threat-focused attention
A cognitive bias in which attention is directed toward perceived threats, including bodily sensations or emotional states.

Avoidance behaviours
Actions aimed at reducing distress by withdrawing from or avoiding perceived threats, often maintaining anxiety over time.

Compensatory behaviours
Actions intended to counteract or control perceived problems (e.g., overworking, excessive reassurance seeking), which may inadvertently maintain distress.

Capitulatory behaviours
Patterns of giving up or disengaging in response to perceived inability to cope, often associated with withdrawal or reduced functioning.

Regulatory capacity
The ability of the body and mind to return to a stable baseline following stress or activation.

Autonomic flexibility
The capacity of the nervous system to shift effectively between states of activation (stress) and recovery (rest).

Neuroplasticity
The brainโ€™s ability to reorganise and adapt in response to experience, learning, and environmental demands.

NeuroAffective-CBT (NA-CBT)
An integrative cognitive-behavioural framework that incorporates physiological regulation (sleep, exercise, nutrition) into psychological formulation and intervention.

TED Framework (Tiredโ€“Exerciseโ€“Diet)
A model within NA-CBT focusing on three core regulatory domains: sleep/fatigue, physical activity, and nutrition.

Regulatory load
The cumulative demand placed on physiological and psychological systems, influencing emotional stability and cognitive function.


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Related studies:

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