The Transdiagnostic Application of NeuroAffective-CBT: A Case Study of Chronic Stress and Burnout

Dr Marco Cortez (UKCP, MBACP)


Abstract

This case report describes the application of NeuroAffective-CBTยฎ (NA-CBTยฎ) with a single working mother, Susan, presenting with chronic stress, shame-organised self-criticism, affective instability, and fluctuating anxiety and low mood. The article may be relevant for clinicians working with clients who โ€˜understand their patternsโ€™ cognitively but struggle to sustain regulation under stress.

Although Susan demonstrated motivation and cognitive insight consistent with traditional CBT, therapeutic progress was initially constrained by physiological dysregulation and entrenched affective patterns. NA-CBT was therefore selected for its neurobiologically informed, transdiagnostic framework (Mirea, 2018). Central to the intervention were the Pendulum-Effect formulation and the TED (Tiredโ€“Exerciseโ€“Diet) module, which supported affect regulation and consolidation of learning. Outcomes indicate improvements in emotional stability, behavioural consistency, and self-compassion. The case highlights both the clinical utility and the limitations of NA-CBT within a time-limited therapeutic context characterised by ongoing psychosocial stress.

This case offers a clinically grounded illustration of how an affect-regulation-first, transdiagnostic approach may be applied to chronic stress and burnout-adjacent presentations, where cognitive insight is present but sustained behavioural change is constrained by physiological and shame-organised responding.

Keywords: NeuroAffective-CBT; affect regulation; shame; behavioural experiments; Pendulum Effect; TED model; psychological flexibility; embodied cognition; transdiagnostic psychotherapy; lifestyle interventions; affective neuroscience; case study


Introduction

Cognitive Behavioural Therapy (CBT) is an established evidence-based treatment for anxiety and depressive disorders (Beck, 1976; Hofmann et al., 2012). However, CBT may be less effective for clients whose difficulties are dominated by chronic shame, affective dysregulation, and embodied stress responses, rather than by explicit cognitive distortions alone (Gilbert, 2010; Panksepp, 2011).

NeuroAffective-CBT extends traditional CBT by explicitly integrating findings from affective neuroscience, attachment theory, and psychophysiology (Mirea, 2018). NA-CBT proposes that durable cognitive and behavioural change depends on the regulation of subcortical affective systems and bodily states, particularly in individuals experiencing persistent emotional volatility and shame-organised responding (Mirea, 2018; Schore, 2012).

This paper presents a detailed, practice-based case study illustrating the application of NA-CBT with a single working mother whose presenting difficulties were coherently conceptualised using the Pendulum-Effect formulation. As a single-case report, the aim is not to necessarily establish efficacy but rather to provide a clinically grounded illustration of how affect-regulation-focused interventions may support therapeutic engagement and change in complex, non-diagnostic presentations.


Client Information

The client, referred to as Susan, is a 42-year-old single mother of two children, one of whom has significant additional needs. She works part-time in a professional role and experiences ongoing financial strain, chronic fatigue, and emotional overwhelm. Susan self-referred for therapy due to persistent anxiety, low mood, bodily tension, and difficulty initiating and sustaining work-related tasks.

She reported no previous experience of psychological therapy and denied suicidal ideation or risk to others. Her difficulties were longstanding and had intensified in the context of prolonged caregiving demands and occupational disruption. Although Susan did not meet formal criteria for occupational burnout, her presentation reflected core burnout features including emotional exhaustion, reduced task initiation, and shame-organised overcompensation.


Presenting Difficulties

Susan reported the following difficulties:

  • persistent tiredness and bodily pain
  • anxiety related to finances and perceived competence
  • fluctuating mood states rather than sustained depression
  • strong self-criticism and pervasive shame
  • cycles of overworking followed by avoidance and emotional shutdown

Despite insight into her thinking patterns, Susan struggled to implement consistent behavioural change. Emotional reactions were often rapid, intense, and disproportionate to present-day triggers, suggesting affective processes operating beneath conscious cognition and outside deliberate control (LeDoux, 1996; Mirea, 2025).


Rationale for NeuroAffective-CBTยฎ

Although Susan met many criteria for standard CBT suitability (Safran et al., 1993), her difficulties were better explained by affective and physiological dysregulation rather than faulty beliefs alone or a discrete diagnostic category. Instead, her presentation reflected a cluster of symptoms common across common mental health presentations, organised around shame-dominant affective responding and chronic stress exposure.

NA-CBT was therefore selected to:

  1. Address emotional reactivity at a neuroaffective level
  2. Reduce shame-organised responding
  3. Stabilise physiological states that interfered with learning
  4. Support belief change through emotionally salient experience

When affective systems are chronically activated, cognitive techniques may inadvertently intensify self-criticism or compensatory over-effort (Mirea, 2018). This pattern was observed during the early phase of Susanโ€™s therapy, further supporting the need for a regulation-first approach.


Pendulum-Effect Formulation

A core feature of NA-CBT is the Pendulum-Effect formulation, which conceptualises psychological distress as oscillation between opposing coping strategies driven by unresolved core affect (Mirea, 2018). These oscillations occur largely outside conscious awareness and function to maintain dominant affects such as shame, guilt, fear, or self-criticism.

In Susanโ€™s case, this oscillation was pronounced. She alternated between procrastination (intentional delay) and avoidance (withdrawal) until tasks became unavoidable. These phases were then followed by periods of overcompensation marked by excessive responsibility-taking, urgency, and perfectionistic standards. Such efforts were typically unsustainable and culminated in collapse, accompanied by intensified self-blame, hopelessness, and emotional withdrawal (or capitulation). A similar pendulum pattern was observed in her eating behaviour, in which episodes of overeating (overcompensation) were followed by periods of restriction (avoidance) and harsh self-reproach (capitulation), further reinforcing shame and loss of self-trust.

Within the Pendulum-Effect formulation, these patterns reflect the complex and dynamic oscillation between avoidant, overcompensatory, and capitulating strategies rather than a linear sequence of behaviours. Shame-based core affect was conceptualised as occupying the functional centre of the system, with oscillating strategies serving as complex self-sabotage, to temporarily manage distress while simultaneously reinforcing negative self-evaluative beliefs such as โ€œI am inadequateโ€ or โ€œI am failing.โ€ Importantly, these strategies were understood not as pathology, but as historically adaptive survival responses shaped by cumulative relational, developmental, and contextual stress (Mirea, 2018; Porges, 2011).

Therapeutic work therefore focused on reducing the amplitude of oscillation rather than eliminating emotional experience, while gradually introducing adaptive coping strategies aligned with authentic personal values that promote psychological health and functional independence. Intervention emphasised affect regulation, increased awareness of pendulum dynamics, and the cultivation of compassionate choice at moments of activation, thereby supporting greater stability and flexibility in emotional and behavioural responding.

Pendulum Poles Identified

Susan oscillated between the following coping poles:

  • Overcompensation: excessive responsibility, perfectionism, overworking
  • Avoidance: procrastination, emotional numbing, withdrawal
  • Capitulation: resignation, hopelessness, self-blame

Conceptually, this can be represented as:

These responses were understood not as pathology, but as adaptive survival strategies shaped by past and current relational stress (Mirea, 2018; Porges, 2011). An early narrative contributing to Susanโ€™s internalised shame involved comparison with an idealised maternal figure perceived as coping effortlessly, reinforcing beliefs of inadequacy and shame-based self-evaluation.

Therapeutic work focused on reducing pendulum amplitude by strengthening affect regulation, increasing awareness of oscillation patterns, and cultivating compassionate choice, rather than attempting to eliminate emotional experience altogether.


Description of the NA-CBTยฎ Intervention

Module 1: Engagement and Affective Assessment

Assessment emphasised collaborative formulation, mapping Susanโ€™s pendulum patterns, and identifying bodily markers associated with distinct affective states. Emotional responses were normalised as nervous-system reactions shaped by experience and rooted in the brainโ€™s predictive regulatory processes, whose primary function is to maintain physiological survival. This framing supported affect tolerance and therapeutic engagement (Schore, 2012; Mirea, 2018).

Within NA-CBTโ€“informed practice, early sessions are understood as a critical opportunity to establish safety, trust, and a robust therapeutic alliance oriented toward authentic living rather than a life organised around internalised shame states. During this phase, the therapistโ€™s role involves providing guidance and psychoeducation alongside compassion and active listening, thereby supporting engagement while modelling a regulated, responsive, and relationally attuned stance.


Module 2: Psychoeducation

NA-CBTยฎ can appear to be a phased treatment; however, clinical practice demonstrates that modules are applied flexibly and intersect dynamically according to formulation and regulatory needs (Mirea, 2018). Psychoeducation was therefore embedded throughout therapy rather than delivered as a discrete phase.

This approach is consistent with evidence that learning and meaning-making enhance neuroplasticity and psychological flexibility, now recognised as a transdiagnostic protective factor (Kolb, 1984; Davidson and McEwen, 2012; Kashdan and Rottenberg, 2010).

Susan was introduced to:

โ€ข the role of pendulum-effect oscillating strategies in reinforcing shame
โ€ข distinctions between core affect and cognitive appraisal
โ€ข the regulatory function of emotions such as shame (signalling perceived social threat and guiding protective behaviour)
โ€ข the impact of physiological stress on emotional intensity
โ€ข the role of lifestyle stability in moderating affective reactivity

This psychoeducation reduced self-blame and strengthened engagement, consistent with NA-CBTยฎโ€™s emphasis on emotional literacy (Mirea, 2018).


Module 3: TED โ€“ Tired, Exercise, Diet

The TED module was implemented as a foundational affect-regulation strategy rather than as adjunctive lifestyle advice (Mirea, 2023; Mirea, 2025). Within NA-CBTโ€“informed practice, TED targets background physiological instability known to amplify emotional reactivity and undermine cognitive and behavioural learning (Damasio, 1999).

Behavioural changes and corresponding behavioural experiments were introduced across all three TED domains. Within the Tired domain, interventions prioritised sleep regularity and pacing rather than sleep optimisation. Within the Exercise domain, distinctions were made between incidental activity and intentional regulating movement such as yoga or purposeful walking, which were more consistently associated with reductions in affective volatility. Within the Diet domain, psychoeducation addressed the short-term stimulating and longer-term destabilising effects of high sugar intake, reframing reliance on sugar as a stress-driven coping strategy rather than a sustainable energy source.

Susan observed that spikes in self-criticism and shame reliably followed prolonged sedentary days characterised by binge eating and alcohol use. Within the Pendulum-Effect formulation, these patterns were understood as oscillations between overcompensation, avoidance, and capitulation, functioning as a recurring self-reinforcing cycle driven by unresolved shame-based affect.

In response, brief โ€œexercise snacksโ€ were introduced not as fitness goals, but as identity-repair behaviours (e.g., โ€œI am someone who cares for my body and nervous systemโ€).

Susan also noted heightened fear and emotional reactivity following poor sleep, skipped meals, and excessive caffeine intake. Using the TED self-check, these affective shifts were re-contextualised as substantially physiological rather than as evidence of personal failure. This reframing reduced shame and overwhelm, allowing subsequent exposure-based and cognitive interventions to proceed with greater tolerance and engagement.

Where relevant, Susan was encouraged to seek medical or dietetic input to support nutritional adequacy and metabolic stability, consistent with TEDโ€™s positioning as complementary to, rather than a replacement for, healthcare input (Mirea, 2025). Following consultation with her general practitioner, routine blood investigations identified physiological factors (e.g., iron and vitamin D insufficiency) considered contributory to fatigue and fluctuating energy levels. Addressing these factors further supported affect regulation and behavioural engagement within therapy without displacing psychological intervention.

As emphasised by Mirea (2025), within NA-CBT informed practice, lifestyle regulation, affective formulation, exposure, and identity repair are conceptualised as interlocking components of a single regulatory system rather than as parallel or competing therapeutic tracks.


Module 4: The Integrated Self

Within NA-CBT, this phase of therapy focuses on working with specific, emotionally salient (โ€œhotโ€) memories that activate cascades of negative affect and self-defeating behavioural responses. Attending to discrete memory fragments is often more effective than attempting to process broad or global relational narratives, which may become cognitively assimilated over time into fear, guilt or shame-based conclusions that are resistant to change (Erten MM, 2018; Mirea, 2018).

Clients were supported to maintain present-moment physiological awareness while narrating specific memories in a contained and titrated manner. This process enabled the gradual re-appraisal of trauma-linked affect as tolerable bodily sensation rather than overwhelming threat. Over time, emotional fluctuations were experienced as manageable variations in internal state, supporting acceptance and the integration of a more adaptive and cohesive sense of self (Gilbert, 2010; Mirea, 2018).


Module 5: Coping Skills-Enhanced Behavioural Experiments

Although behavioural experiments are described as a discrete module within NA-CBT, the creation of new lived experience is emphasised throughout therapy, reflecting the modelโ€™s use of intersecting and flexible modules rather than a linear sequence (Mirea, 2018). Behavioural experimentation was therefore conceptualised as an ongoing learning process supporting affect regulation, belief revision, and identity repair.

Across therapy, experiments were designed to test emotional predictions alongside cognitions, consistent with experiential learning theory (Kolb, 1984; Engelkamp, 1998) and the principle that belief change occurs primarily through emotionally meaningful action (Chadwick, Birchwood and Trower, 1996).


Module 6: Consolidation and Ending

Ending focused on recognising early pendulum swings, applying TED independently, and maintaining ongoing affect awareness. Relapse prevention was framed as a process of continued regulation rather than symptom elimination (Mirea, 2018). TED was positioned as a long-term inner compass, with setbacks reframed as signals of nervous-system strain rather than personal failure.


Outcomes

Therapy progressed steadily across 18 sessions. The initial six sessions focused on assessment, collaborative formulation, psychoeducation, and the introduction of the TED framework, with particular emphasis on affect regulation and lifestyle stabilisation.

The subsequent nine sessions facilitated early narrative processing and the development of acceptance through self-compassion. These sessions also incorporated behavioural and social experiments aimed at promoting new learning, strengthening adaptive coping, and gradually modifying overcompensatory, avoidant, and capitulating coping strategies. Such patterns were frequently organised around shame-based conditional assumptions, for example: โ€œIf I do not sacrifice myself and meet othersโ€™ demands perfectly, I am worthless,โ€ accompanied by implicit affective experiences of shame and guilt.

The final three sessions were conducted on a monthly basis and focused on consolidating therapeutic gains, strengthening relapse-prevention strategies, and supporting the clientโ€™s increasing capacity for autonomous self-regulation.

By the end of therapy, Susan demonstrated:

  • Adoption of a more regulated lifestyle informed by TED principles
  • Reduced affective volatility and improved emotional self-regulation
  • Increased tolerance of uncertainty and distress
  • Greater behavioural consistency across work and caregiving contexts
  • Development of a more compassionate and flexible self-narrative

Although significant external stressors persisted, Susan experienced emotional responses with greater awareness, reduced escalation, and increased capacity for regulation, indicating meaningful consolidation of therapeutic learning.

Symptomatic progress was monitored using the Hospital Anxiety and Depression Scale (HADS) and CORE-32, administered at assessment, session nine, and session eighteen. Improvements were observed across key domains of concern, including chronic stress, day-to-day functioning, shame-organised self-criticism, affective instability, anxiety, and low mood.


Learning Outcomes

This case demonstrates that:

  1. โ€œAffect regulation may be a prerequisite for sustained cognitive and behavioural change.โ€
  2. โ€œThe Pendulum-Effect formulation offers a dynamic, non-pathologising framework for understanding oscillating coping patterns.โ€
  3. โ€œTED-based interventions can function as core therapeutic tools rather than adjunctive lifestyle advice.โ€
  4. โ€œBehavioural experiments are most effective when designed to be emotionally salient.โ€
  5. โ€œNA-CBT may be particularly well suited to presentations characterised by chronic stress, low self-esteem, and shame-organised responding.โ€

Critical Evaluation

Strengths

  • Integrates affective neuroscience, lifestyle regulation, and principles from nutritional psychiatry within an evidence-based CBT framework
  • Reduces self-blame through the normalisation of physiological and affective processes
  • Provides a coherent and non-pathologising framework for complex, non-diagnostic presentations

Limitations

  • Requires advanced therapist skill in affective attunement and regulation
  • Requires additional therapist knowledge drawn from domains that traditionally fall outside the core remit of psychotherapy, including nutrition, neuroscience, and exercise psychology
  • Some concepts may initially feel abstract or unfamiliar to clients
  • Time-limited therapy constrained the depth of narrative integration and longer-term consolidation

Clinical Reflexivity

With hindsight, earlier emphasis on TED-based stabilisation may have reduced initial pendulum oscillations more rapidly. Encouraging liaison with primary healthcare services, including general practitioner consultation and routine blood investigations, provided clinically useful contextual information that complemented psychological formulation and supported affect regulation.

This early physiological stabilisation facilitated increased engagement in self-care and self-compassion practices, which in turn enabled deeper therapeutic work with shame-laden narratives, including beliefs linking personal worth to constant performance and self-sacrifice.

Agenda management required ongoing sensitivity to balance therapeutic structure with respect for the clientโ€™s lived complexity, ensuring that therapeutic direction did not inadvertently replicate earlier experiences of invalidation or over-demand.


Conclusion

This case illustrates how NeuroAffective-CBT can extend traditional CBT by directly engaging the affective and physiological processes that organise psychological distress. Through the combined use of the Pendulum-Effect formulation and TED (Tiredโ€“Exerciseโ€“Diet), NA-CBT supported sustainable emotional and behavioural change within the context of ongoing psychosocial stress. Rather than functioning solely as a time-limited intervention, NA-CBT may be understood as a lifelong self-regulation framework, offering clients a practical internal compass for stabilising physiology first and thereby expanding freedom in how they think, feel, and act.

More broadly, this case reflects a growing movement within psychotherapy toward a deeper integration of mind and body. As neuroscience, psychosomatic medicine, nutritional psychiatry, and biologically informed treatments increasingly converge, it is becoming difficult to justify approaches that address cognition and emotion in isolation from physiology. Integrative models such as NA-CBT are well positioned to contribute to this evolving landscape by offering clinicians a coherent framework that bridges affective neuroscience with everyday therapeutic practice (Mirea, 2025).

NA-CBTยฎ positions itself not merely as a set of techniques, but as a compassion-centred, neurobiologically informed psychological approach. While many traditional psychotherapeutic schools have historically approached lifestyle factors with caution, emerging evidence and clinical experience suggest that disrupted sleep, nutritional instability, and insufficient movement are pervasive across mental health presentations and frequently undermine therapeutic progress. Addressing these factors thoughtfully and collaboratively does not dilute psychological depth; rather, it creates the physiological conditions necessary for insight, emotional processing, and behavioural change to take root.

From this perspective, interventions such as TED are not ancillary to therapy but foundational. Encouraging appropriate medical collaboration when clients present with chronic fatigue or low energy can help identify modifiable physiological contributors that, when addressed, enhance affect regulation, therapeutic engagement, and overall quality of life. Such integration reflects a broader shift away from symptom-focused treatment toward whole-person care, where psychological flexibility, embodied awareness, and compassionate self-regulation become central therapeutic outcomes.

Taken together, this case suggests that the future of psychotherapy may lie less in refining ever more specialised techniques and more in developing integrative, transdiagnostic frameworks capable of holding mind, body, affect, and behaviour within a single coherent model. NA-CBT offers one such framework, grounded in neuroscience, oriented toward compassion, and designed to meet the complex realities of contemporary clinical practice.

Future Directions for Psychotherapy

The evolving landscape of mental health care increasingly calls for psychotherapeutic models that move beyond rigid diagnostic categories and isolated treatment techniques. As research continues to clarify the reciprocal influence of physiology, affect, cognition, and behaviour, future psychotherapy is likely to become more integrative, transdiagnostic, and biologically informed.

Approaches such as NeuroAffective-CBT point toward a future in which affect regulation and nervous-system stability are recognised as foundational prerequisites for psychological change. Rather than positioning lifestyle, embodiment, and self-regulation strategies as peripheral or adjunctive, emerging models are likely to incorporate these elements centrally within formulation and intervention. This shift has the potential to enhance treatment accessibility, durability of outcomes, and client autonomy.

Future developments in psychotherapy may also involve closer collaboration between psychological practitioners and other health disciplines, including primary care, nutritional psychiatry, and psychosomatic medicine. Such interdisciplinary integration may support earlier identification of physiological contributors to emotional distress and reduce unnecessary chronicity across mental health presentations.

Finally, the field may increasingly value therapeutic frameworks that prioritise psychological flexibility, compassion, and embodied self-awareness over symptom suppression alone. In this context, psychotherapy may evolve from a primarily corrective endeavour into a developmental process, one that supports individuals in cultivating sustainable self-regulation, resilience, and a more integrated sense of identity across the lifespan.


Disclaimer

This case study is intended for educational and professional discussion purposes only. It does not constitute clinical guidance, diagnosis, or treatment recommendations. Therapeutic approaches described should be applied only by appropriately trained professionals and adapted to individual client needs. Readers are advised to consult relevant clinical guidelines and professional supervision when translating concepts into practice.

Ethics and Anonymisation Statement

All identifying client information has been altered to protect anonymity. Informed consent was obtained for the use of anonymised clinical material for educational and dissemination purposes.


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If my gut could talk to me, what would it say ?

Introducing Jamesโ€ฆ

James is a successful banker enjoying significant authority and respect at work. Being into sports and a healthy lifestyle, he is tall and handsome, he has a beautiful wife and two children. On paper all is well, and so he would be taken by surprise every weekend when visiting his parentsโ€™ home for Sunday lunch, by the experience of intense, discomforting, and painful butterflies, in anticipation of this recurring event. He is left confused, without an explanation.

Allowing for an earlier narrative to unfold within the first few hours of therapy, childhood experiences were revealed, where he experienced similar painful feelings, generated by a critical and highly demanding father, the kind of parent that would be difficult to please. His mother never interfered and to James, this was as bad as his fatherโ€™s attitude. His childhood was dotted with various episodes of unfavourable comparisons with a younger and brighter sister. 

Despite his success and handsome appearance, he sees himself as ugly, unattractive, unwanted, enjoying some professional success through sheer luck, an impostor, and a trickster. He remained hypervigilant throughout the years around his father and eager to be validated. He gets overwhelmed with anticipatory anxiety before every single meeting with his parents.

When gently exposed to these issues during therapy, he acknowledged a connection with early experiences right away, he realised that he feels the same way around other men or women in authority, and yet he remained equally confused and troubled by these dominant, painful gut-feelings1.

******

โ€˜I can feel it in my gut‘ or โ€˜trust your gutโ€™ we often say to ourselves or each other, perhaps for very good reasons. Scientists have recently established clear links between our gut and the brain, not necessarily through an analysis of the diversity of the microbiome that exists within our gut, although this turns out to be equally relevant (Skonieczna-Zydecka K et al., 2018), but also by paying attention to the actual structure of the gut at a cellular level (Kaelberer M et al., 2020).

The biological dimension

Dr Kaelberer and colleagues identified a direct pathway from the gut to the brain, that essentially allows sensing of what is happening in the gut, in order to inform specific emotions whether pleasure or disgust, and the resulting behaviours. This would, at least in part, explain cravings and associated compulsive actions, and furthermore, it helps explain why the regular practising of mindfulness or paying calm, non-judgemental attention inwards, could lead to a shift in feelings and better emotional-regulation (Golding and Gross, 2010).

The gut-brain communication happens through versatile and adaptable neuropod cells with electrical sensors within the gut structure, which are able to select and specialise in various essential chemicals like glucose, proteins or amino acids. These cells can program to organise digestion and send information via electrical signals straight to the brain, which will make further informed decisions on what to feel and how to respond to certain products, in a given situation. Although not the only sensorial command centre, it does appear that, the human 9- to 10-meter-long gut, could be the largest internal organ with immediate access to the external world.  Running through the upper body, from the rectum to the esophagus, and in constant communication with the brain, the gut is able to provide an individual, with a fuller experience of what it means to engage with useful edible products, like enjoying a coffee with a cookie in the morning, where the individual is likely to experience both pleasure and a sudden increased in energy. Seems ‘the gut’ may indeed be one of the biggest organs inside our body, but reaching as far as the external or the social world, is not something psychologists would have taken into account until now.

Inside the gut something equally fascinating takes place, which further strengthens the relationship between the human gut and the brain. Our intestine has about 39 trillion microorganisms called microbiome and it consists mostly of bacteria, viruses and fungi – the microbiome produces chemicals which can send messages to the brain through the vagus nerve. This nerve starts in the brainstem, it travels down the neck and alongside the carotid arteries and into the chest branching out towards internal organs, as a result it can manage gut contractions (peristalsis) and heart rate – this makes the vagus nerve relevant when it comes to the human relaxation response.

We now know, that people who suffer from chronic stress have very different microbiomes and โ€˜badโ€™ bacteria that produce inflammation, as opposed to a healthy individual who would have a diverse population of bacteria strains. This has serious clinical implications and recent research has in fact shown, that levels of depression would improve when injected with a specific bacteria (faecal). Although these bacteria is proving difficult to reproduce artificially in a lab, the link between the gut micorbiome and the brain explains why certain diets, like the Mediterranean diet, and foods (like pre/probiotics) would have a direct impact on the mood. A healthy diet is associated with a 30% reduction in depression.

Good gut health means good overall health !

The psychosocial dimension

Humans like most other mammals have rituals around eating, drinking and socialising. Such events are usually inter-linked and incredibly important to evolution. Those are ideal occasions to get to know one another, to court each other, to test our emotions, bond and reproduce. Often a potential partner is treated to a freshly cooked meal with a personal touch. This enhances the possibility of having a relationship. Social rituals such as feeding a child, courtship or even kissing, demonstrate how the gut is constantly interacting with the brain and through a perfect symphony of electrical signals, enzymes, and various chemicals, it assists with social bonding, and the selection of the most appropriate partner. This is where the notion of โ€˜butterflies in the stomachโ€™ takes a completely different meaning when two lovers meet, versus two people shouting at each other in extreme anger. All individuals involved in these very different scenarios, would report experiencing butterflies in the stomach with different levels of intensity. This turns out to be nothing short of cells and electricity at work, dutifully completing their shift. Just another day in the office.

Through stories we reach the world around usโ€ฆ

 Homo-sapiens are also โ€˜homo-narransโ€™ (Meichenbaum D, 2017). We have an innate ability to observe our own thoughts, to think about our thinking in vivid images, pictures, or even short video clips, and ultimately describe with various details, the content of our thoughts and conclusions. This is what we label as โ€˜storiesโ€™. In fact, we rarely think in clear and brief thoughts, but instead our minds, seem to be dominated by stories involving all sensory modalities, a pleasant memory of a sensual encounter has sounds, smells and tastes, alongside vivid video-reels which unconsciously lead to arousal.

  โ€˜The early bird catches the wormโ€™.

We grow up ‘feeding’ on stories, symbols and metaphors; most of us will remember with great pleasure childhood messages and proverbs repeated to exhaustion by our parents and grandparents, in the hope that we would learn to behave more appropriately, in line with our social context and culture. The messages we remember the most, have an interesting narrative behind them, rich in details and sensorial pleasures. The teacher that inspired us during school years, was most likely, the best storyteller. Story telling is a natural gift often unexplored and unnourished.

Stories we tell ourselves reflect earlier experiences and are used as a learning platform. They have to make contextual sense of the world we live in, and as such, our personal narratives, are influenced and adapted over time in order to fit in, with continuously evolving circumstances (Hickes and Mirea, 2012). This would of course, in turn, ensure survivability and psychological resilience over the course of lifetime. Failure to update old narratives can create psychological rigidity, which leads to internal distress and therefore, predispose individuals to mental illness.

Indeed, this fascinating oval-shape mass of grey, which we refer to, as the โ€˜brainโ€™, is plastic. In other words, it has the ability to biologically modify itself and adapt to new circumstances (another area the conscious mind1 is not consulted about), with only one important mission that supersedes everything else – keeping us alive! Therefore, the stories we tell ourselves are not designed to generate feelings of happiness or sadness, since those are not essential to our survival. Although we know this is at times possible, the brainโ€™s main priority is to keep the organism or the body as a whole, functional and alive.

The cognitive-behavioural dimension

 When the gut communicates with the brain, it is purposeful, and it demands an immediate reaction. Intense emotions lead to compulsive behaviours, bypassing the mind completely, e.g., when one is hungry, the resulting senses, known as cravings or feelings of pain and discomfort in the gut area, lead to an urgency to find something to eat, the mind is simply trying to resolve this problem by going to previously memorised solutions.

Therefore, cognitions are products of an extremely busy brain with no time off. Best understood as essential components of a regulatory system informed by thought, experience, memory, language, sensorial data or felt-sense2, and deeply-rooted beliefs3. It may not always be easy, but it is possible to override oneโ€™s felt-sense or gut-feelings, if we start engaging our prefrontal abilities by reframing the experience and simply view DRBs as, the dialectical expression of a felt-sense. This can be achieved through new learning, and new experiences. Humans, unlike other mammals, do this all the time, we are very good at convincing ourselves that something is good for us, through repetition or rehearsal, when in fact, our gut is telling us that the opposite is true. For example, eating lots of sugar, drinking alcohol or smoking. In a different context, it could be argued that learning how to override painful gut-feelings, might be the very purpose of a psychotherapeutic treatment specifically, helping individuals overcome painful gut-feelings, or felt-senses which internally suggest they are flawed or not good enough.

Deeply-rooted beliefs might be best understood as the first layer of defence, a deeper screening or filtering system that helps an individual navigate through the complexities of life, in spite of a dominating gut-feeling that he is not good enough. These types of senses are reminders of previous experiences and nothing short of โ€˜brain statementsโ€™ or brainโ€™s best possible interpretation of early life experiences. Whether frequent exposure to extended periods of affection, or at the other end of the spectrum exposure to neglect, characterised by intense pain signals and experienced mostly by the gut, and felt within the upper body regions. Since our brain does not use language per se, to โ€˜shout outโ€™ warnings to the mind, various electrical signals are sent back and forth between brain structures and different parts of the gut, on every single occasion we find ourselves in a situation that points toward a reward or indeed a threat (i.e., neglect). Sensorial signals alerting an individual of a potential reward or threat, depending on the developmental stage, could be processed linguistically and translated into deeply-rooted beliefs of lovability (pleasure) or unlovability (rejection), but this is rarely needed outside of a therapy session. And of course, lack of awareness and language speeds up the process of getting a reward or running away from neglect or threat. Once the Mind gets involved, everything slows down and is investigated with the curiosity of a scientist.

We have now understood that DRBs are not seen or heard but felt deep inside the body at a gut level and they are not interpreted by a mind which does not even fully develop before the age of two. Therefore, not only that language is not needed when chasing a reward or running away from a threat, but DRBs have no immediate linguistic correspondent, since the gut-brain axis is bypassing the temporal lobe responsible for language processing. Studies suggest that the prefrontal cortex, or the ‘mind’, starts developing within the first two years of life, since basic brain structure and connectivity is present by this age (Huttenlocher & Dabholkar, 1997), but continues until the mid-twenties, which marks an end to our adolescent stage and a slowing down of brain neuroplasticity (Siegel D, 2020). 

Attachments and emotional neglect

British developmental psychologist and psychiatrist John Bowlby is one of the most recognisable names associated with attachment research (1988). His evolutionary theory suggests that children come into the world biologically pre-programmed to form attachments with others, since this will help them survive. Indeed, a child that has been emotionally neglected by one of his main caregivers, might not have been a victim of a physically or sexually aggressive parent, nonetheless the child would internalise the absence of warmth and physical affection as threatening, incredibly painful, confusing and difficult to navigate. A child depends for many years on his parents, in order to survive and thrive. And therefore, to a child, the prospect of disappointing a parent is a risky business. Chronically it would be painful, with many types of manifestations and physiological symptoms, like muscle spasms or butterflies inside the body. Not being able to process the experience of rejection or make any sense of it, the gut-brain axis constantly makes decisions on what is healthy and what is not. Eventually these decisions are introduced into our contextual world via stories that we imagine and tell ourselves. These early narratives have implicit deeply-rooted beliefs, not yet linguistically formulated but with clear sensorial messages and themes centred around unlovability, rejection, unworthiness or unacceptability. When finally expressed or spoken โ€˜out loudโ€™, the language is as varied as individualsโ€™ backgrounds, largely subjected to individualsโ€™ culture, education, imagination and linguistic skills.

Perceived social threats such as criticism and rejection or the prospect of living alone, can be frightening because the gut does not like neglect or going without. Emotional neglect is a real threat in childhood, because it is synonymous with deprivation of essentials, including food and ultimately death. Humans bond to survive. The threat of being alone is basically unbearable to the gut and body by extension.

Deeply-Rooted Beliefs and Contextual-Acceptance

When He says, He is ugly, He also means โ€˜โ€™The world does not like Meโ€™โ€ฆ and this is the part that really frightens.

 It could be speculated that emotional neglect is more impactful on the gut because of the physiological deprivation suffered by the organism. Deprivation of positive affection is associated with lack of appetite or compensatory appetite which leads to the production of specific enzymes and hormones. Whereas, with other types of exerted aggression, the gut suffers less organic deprivation, refocuses on healing, and learns to reprogramme itself allowing for adaption of the whole organism (Kaelberer M, et al., 2020). This could explain why in certain cultures, where physical discipline is widely spread, the actual โ€˜physical abuseโ€™ does not lead to post-traumatic stress, and it has little or no impact on the immunity and physical health. This type of parenting is not perceived as abusive within the community at large because biologically, it is not significantly harmful, and the emotional dimension is invisible and easier to ignore. The parenting model is therefore normalised, perceived as efficient and often replicated by other families. These sophisticated lines of defence could be viewed as a type of socio-homeostatic process or organismโ€™s attempt to repair and adapt itself through the practice of cultural values and contextual-acceptance.

 Deeply-rooted beliefs therefore, may have a regulatory purpose and essentially teach the organism, or the body to adapt.

โ€˜My dad was a little hard on me yesterday, sorry I could not meet you but, I was in a bit of a stateโ€™โ€ฆ Friend replies: โ€˜your dad is fine, you should meet mineโ€ฆ but to be fair, I still hate my homework and love to sneak out for a smokeโ€™.

In a practical sense, to survive and even thrive in, what could be perceived as a harsh environment, requires normalising and acceptance of external living conditions, also coined in this paper, as โ€˜contextual-acceptanceโ€™. Whilst seeing the world through myopic unlovability lenses, James has to adapt to various contexts and whatever else life throws at him, in order to continue to survive and grow in spite of, a dominating felt-sense which strongly suggests he is unappreciated, and likely to be rejected.

โ€˜Since nobody likes me, I have to make more effort than anyone else and behave in ways that will ensure I am safe – despite what everyone really thinks of meโ€™James would often think to himself, during moments of self-reflection. This type of contextual-acceptance can override the dominating gut-feeling, it leads to psychological adaptation and resilience. When contextual-acceptance is denied, an episode of emotional crisis would be inevitably triggered.

 The regulatory quality of deeply-rooted beliefs, also means that they can be accompanied by both negative and positive affective experiences. Someone falling in love or desiring someone sexually feels an acute pain inside the body, within areas of the gut, but this is not registered in a negative manner by the brain and, since it is not a threat, it does not activate fear and avoidance.

By contrast, just thinking about food when hungry can lead to secreting specific enzymes and further compulsive eating behaviours. Going for a driving test can lead to feeling sick in spite of being well prepared.  At times, people throw up when faced with social fears and other times they avoid a challenging test all together. It all seems to depend on the lenses the individual uses, because sure enough, when individuals look at the outside world through their unlovability lenses, the whole world would appear likely to reject them, no matter how well behaved they are. It takes effort and motivation to override the gut-feeling. Deeply-rooted beliefs therefore, create myopic lenses but contextual-acceptance heals the pain that comes with it.

Conclusions

Deeply-rooted beliefs have been characterised in the psychotherapeutic literature as schemas by Jeffrey Young (2003) and Paul Salkovskis (1996), core organising principles, often sounding like a code of honour, which the individual cannot afford to break, the cost would be too high, and yet consciously unknown. As such, Jamesโ€™ life was rigidly governed and guided by his unlovability and worthlessness telescope-type lenses

DRBs are the lenses through which we see the world and ourselves. Supported and confirmed by the gut and with help from specific brain structures, they act as deeply rooted filters, allowing into our consciousness only what the gut-brain-axis feels is relevant to our survival. And as we have already established, the human gut and brain, are not concerned with our happiness or material wealth.

However, the axis is capable of both good and evil and can be persuaded to change and reprogramme the lenses through which we see our life, through an ample process of education and self-awareness, new learning and new coping practices, all key aspects of change. It appears that, just like with any other muscle, all organs inside our body need retraining with consistency over time. 

There is nothing more captivating than an authentic story which can send clear motivational messages about meaningful changes and potential solutions. People have been preoccupied with sharing their ideas, personal stories, discoveries, and inventions for thousands of years.  Historical writings and drawings on the cave walls are testimony to that fact. Telling ourselves and each other stories, is so embedded within our psychological framework, it has become an essential part of our existence, for where would we be, if it was not for our stories? We tell stories to confirm and justify our very existence. 

It appears that stories are very likely, part of our genetical make up and therefore it is not much of stretch to consider that internal storytelling or the narratives we repeat to ourselves, are not only generated, but also perpetuated by our felt-senses or gut-feelings, designed to cement beliefs about who we are, how we could fit into our world, how we need to behave, and what our future prospects are.

Some of our gut decisions are truly worthy of our trust, but we have demonstrated how at times, the gut is misinformed by neglect and emotional deprivation. It falls onto the therapist to guide the patient4 with sensitivity, kindness and compassion, through the sea of vast, often stormy narratives, in order to make sense of the deeply-rooted beliefsโ€™ images, sounds and smells, covert meanings and values.

Perhaps because deeply-rooted beliefs are primarily supporting a survival instinct, those are not always in sync with ideal and current personal values, generated by a fast pacing, ever-changing society. The modern world, the speed of development supported by human creativity, forces us to constantly work on redefining what authentic living means, based on contextual-acceptance.

Whatever this means for each individual, it can only be achieved by constantly refocusing the lenses through which we see ourselves and others, and override deeply-rooted beliefs that support an older way of living or dated values. Charles Darwin, a passionate evolutionary biologist, and author of โ€˜The origins of speciesโ€™ (1859) might have been among the first to note that organisms, much like the human organisms with all their guts and brains, would never fail to either adapt or die. It is simply a question of survival.

The โ€˜Gut – Brain – Affectโ€™ triangle: paving the way to future research and development

Traditionally, psychotherapists have been more interested in the interplay between mind, feelings and actions that lead to โ€˜psychological painโ€™ often without being able to answer questions about the subjective feeling of โ€˜sufferingโ€™. Where is all the ‘suffering’coming from, and what are its main characteristics?

  The notion of โ€˜deeply-rooted beliefsโ€™ attempts to answer this dilemma by proposing an investigation into the fascinating world of the ‘gut-brain-affect’ triangle. Searching for answers in an area, that has not been fully explored by psychology just yet, is more than challenging and leads to more questions than answers. At the same time, new and older research studies from physiology, nutrition, attachments, and neuroaffective-biology seem to open a world of therapeutic possibilities.  

If the gut and the brain are in constant and autonomous communication (or outside of our awareness), and they make behavioural decisions for us all the time, then it is safe to assume that nutritional and other daily occupational habits, such as the proverbial rest, work, and play, could impact more significantly on our mental health, than ever anticipated (Mirea, 2023). We have always known this instinctively, but the bio-psycho-social processes operating in the background remain a mystery.

This review barely scratches the surface of an intricate world of internal highways of communication, hidden within the human infrastructure, which ultimately leads to behavioural and social decisions, every moment, of every single day. Decisions that ultimately, impact on our wellbeing, quality of life and overall existance.

The article certainly raises more questions than answers, we do not seem to fully understand all the mechanisms that support gutโ€™s constant communication with the brain. But if indeed โ€˜we are what we eatโ€™ then, psychologists and psychotherapists need to start paying more attention to how nutrition is impacting on our mental health, not just the physical health. Perhaps it falls on the domain of evidence-based psychology to align itself with relevant research from the fields of nutrition, physiology, or neuroscience, in order to better understand the individualsโ€™ relationship with food, digestion, hormones and mental health as well as the environmental impact.

Some progress has been noted in understanding the links between the gut microbiome and depression, but much remains undiscovered and sadly, the psychotherapy community continues to remain silent and uninvolved.  This article therefore assumes the risk of going into unchartered territories, potentially exposing many gaps within psychotherapy research. It points toward the sophisticated inner technology of the gut-brain-affect axis with significant implications for mental health treatments. Letโ€™s consider for instance, the relationship between our integumentary system5, emotions, sensations of pain, pain management and mental health. This is an area insufficiently explored within psychology outside of the CBT and Hypno-CBT6 arena.

An example much closer to the subject discussed in this article, would be the potential value of investigating the intestinal chemical formula, that informs us when and if, a product is good for us, and as such, is it worth pursuing in the future. Products consumed are only good, when they are not poisonous for the system, but also when the situation or the context is favourable, in other words, where and when these are consumed. An example would be, when a serious meat eater goes to a new vegetarian restaurant in town that serves an almost too ‘adventurous’ menu for him. On paper this should be a failed event but the ‘context’ takes over completely and so if the individual is in good company, like a date or with someone he actually likes to spend time with, the affective-response changes to joy and pleasure. Through associated learning, a product becomes even more rewarding, and the experience is more likely to be repeated, if the place where the product was discovered, as well as the company kept at the time, were equally rewarding. Culture, existential and personal values, conditioning and social learning theories, memory and language processing, neuroscience, biology and nutrition, all these research domains come into this one simple social experience, which is repeated by tens of thousands of humans every day. Learning theories only partly explain these social decisions and bonding events because, there is an entire domain of the digestive and sensory system that we haven’t even began to articulate in this paper. The same could be said about the links between the digestion system, memory, and language processing. How we describe linguistically an experience, impacts on how we feel about it!

Developing psychotherapy tools such as NeuroAffective-CBT (NA-CBT), which successfully integrates research from all of above mentioned domains, could pave the way for a fourth-wave7 of evidence-based psychotherapy practices (Mirea, 2012). NA-CBT is a transdiagnostic approach, which means that it does not rely on a psychiatric diagnosis and a prescribed treatment protocol, that integrates successfully nutritional advice, physical strengthening programmes, sleep training, and bloodwork analysis (i.e., the TED model, Mirea 2005/2023) alongside traditional behavioural and cognitive interventions. Similarly, future fourth-wave schools of Integrative-CBT8 would aim to improve self-efficacy and enhance individualsโ€™ ability to listen to their bodies, essential skills that claim control over immunity and health overall.

No longer separating the mind from the body in at least, some of the research, might be an obvious step in the right direction.  And, perhaps accepting the inevitable – the practice of positive, evidence-based psychology, may be in total contradiction with what we are taught by society that we need, in order to be high achieving and forward moving in life. Modern culture is about learning to override the signals from the body though it seems, at least some of the time, the exact opposite is what humans need. Learning to listen to the signals from the body might be the one of the keys that open the door to healthier living.

Glossary:

1The Mind, or the conscious mind, these terms simplistically refer to higher structures of the brain including the prefrontal cortex (PFC), the section of the brain located behind the forehead; this particular area may be responsible for decision making and finding solutions.

2Felt-Sense, Gut-Sense, Gut-Feelings are senses which act as reminders of previous experiences, designed to alert us of a potential reward or indeed, a threat. These terms are used interchangeably through the paper.

3DRBs: abbreviation for Deeply-Rooted Beliefs. DRBs could be defined as the dialectical expression of (internally experienced) felt-senses, which are translated linguistically later in life when language becomes available, those could in fact, be (verbally) expressed as late as adulthood, often during therapy for the first time. DRBs forge a rigid identity within individuals at an earlier stage in their lives and therefore are harder to modify outside of the therapeutic environment, evidence against DRBs is disregarded through mechanisms like mental filters, described in detail in this paper.

4Patient or Client are the same terms, used interchangeably through the article, usually depends on the situational context or where the therapist is likely to have a practice, at times we refer to our clients as patients or vice-versa.

5Integumentary system refers to the human skin and its structures, the other largest human organ, besides the human gut, which makes up to 16% of the body weight, and also interacts with the external world and further communicates with different parts of the nervous system constantly and autonomously.  

6Hypno-CBT โ€“ Cognitive Behavioural Hypnotherapy, a transdiagnostic third-wave CBT approach introduced by Donald Robertson and further developed by Mark Davis. Training in Hypno-CBT is offered online and can be accessed here.

7Fourth-wave CBT or the fourth-wave of evidence-based psychotherapy practice refers to the stages of development within the field of evidence-based psychology, CBT in particular. First-wave is marked by extensive behavioural research, this is the foundation of CBT essentially; second-wave brings together research from cognitive psychology and behaviourism; third-wave introduces philosophy and emotional-regulation; fourth-wave is likely to bring along more digital interventions, neuroscience, neurobiology and physiology. For instance, having routinely a blood-test before psychotherapy starts could be considered good practice – since a blood test would point towards physical conditions that have mental health symptoms, like pre-diabetes (Mirea, 2023). ย 

8Integrative-CBT, on short I-CBT was mentioned for the first time at the 9th International Congress of Cognitive Therapy in Transylvania in 2017 @Babes-Bolyai University, event which brought together more than 400 researchers and clinicians from all over the world, event was hosted by Prof. Daniel David, Beck J, Clark D, Hays S and, other renowned clinicians.ย 

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Acknowledgements:

This article could not have been finished without valuable guidance and input from Dr Donald Meichenbaum. Dr Meichenbaum is considered by most the โ€˜Freud of CBTโ€™, one of the three main pioneers, alongside Aaron T Beck and Albert Ellis, of early cognitive and behavioural therapies. Dr Meichenbaum subsequently played an instrumental role in understanding violent trauma, aggressive behaviours, and human resilience.

Editing by Dr D Meichenbaum, SIT and CBT founder; proof reading by Ana Ghetu psychosocial researcher and Dr S Reilly clinical researcher and general practitioner.